6q92
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Arginase-1 at pH 7.0 in complex with ABH== | |
| - | + | <StructureSection load='6q92' size='340' side='right'caption='[[6q92]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6q92]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q92 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q92 OCA], [http://pdbe.org/6q92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q92 RCSB], [http://www.ebi.ac.uk/pdbsum/6q92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q92 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arginase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Grobben, Y]] | [[Category: Grobben, Y]] | ||
| - | [[Category: Zaman, G | + | [[Category: Uitdehaag, J C.M]] |
| + | [[Category: Zaman, G J.R]] | ||
| + | [[Category: Borate]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase inhibitor]] | ||
| + | [[Category: Manganese cluster]] | ||
| + | [[Category: Ph-dependent]] | ||
Revision as of 15:14, 11 December 2019
Crystal structure of human Arginase-1 at pH 7.0 in complex with ABH
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