6tf9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the vertebrate gamma-Tubulin Ring Complex== | |
| - | + | <StructureSection load='6tf9' size='340' side='right'caption='[[6tf9]], [[Resolution|resolution]] 4.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6tf9]] is a 48 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TF9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tf9 OCA], [http://pdbe.org/6tf9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tf9 RCSB], [http://www.ebi.ac.uk/pdbsum/6tf9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tf9 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACTB_XENLA ACTB_XENLA]] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.[UniProtKB:P60709] [[http://www.uniprot.org/uniprot/TBG1_XENLA TBG1_XENLA]] Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. [[http://www.uniprot.org/uniprot/A0A1L8HGZ5_XENLA A0A1L8HGZ5_XENLA]] Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.[RuleBase:RU363050] [[http://www.uniprot.org/uniprot/Q642S3_XENLA Q642S3_XENLA]] Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.[RuleBase:RU363050] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Pfeffer, S]] | ||
| + | [[Category: Zupa, E]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Gamma-tubulin ring complex]] | ||
| + | [[Category: Microtubule nucleation]] | ||
Revision as of 15:24, 11 December 2019
Structure of the vertebrate gamma-Tubulin Ring Complex
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