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6uqf
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human HCN1 channel in a hyperpolarized conformation== | |
| - | + | <StructureSection load='6uqf' size='340' side='right'caption='[[6uqf]], [[Resolution|resolution]] 3.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6uqf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UQF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uqf OCA], [http://pdbe.org/6uqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uqf RCSB], [http://www.ebi.ac.uk/pdbsum/6uqf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uqf ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/HCN1_HUMAN HCN1_HUMAN]] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HCN1_HUMAN HCN1_HUMAN]] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.<ref>PMID:15351778</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lee, C H]] | ||
| + | [[Category: MacKinnon, R]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 15:25, 11 December 2019
Human HCN1 channel in a hyperpolarized conformation
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