4zhk
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of RPE65 in complex with MB-002== | ==Crystal structure of RPE65 in complex with MB-002== | ||
| - | <StructureSection load='4zhk' size='340' side='right' caption='[[4zhk]], [[Resolution|resolution]] 2.09Å' scene=''> | + | <StructureSection load='4zhk' size='340' side='right'caption='[[4zhk]], [[Resolution|resolution]] 2.09Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4zhk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZHK FirstGlance]. <br> | <table><tr><td colspan='2'>[[4zhk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZHK FirstGlance]. <br> | ||
| Line 11: | Line 11: | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN]] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref> | [[http://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN]] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Retinoid isomerohydrolase|Retinoid isomerohydrolase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 16: | Line 19: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Retinoid isomerohydrolase]] | [[Category: Retinoid isomerohydrolase]] | ||
[[Category: Kiser, P D]] | [[Category: Kiser, P D]] | ||
Revision as of 15:55, 11 December 2019
Crystal structure of RPE65 in complex with MB-002
| |||||||||||
