1a31

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[[Image:1a31.gif|left|200px]]
[[Image:1a31.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1a31 |SIZE=350|CAPTION= <scene name='initialview01'>1a31</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1a31", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=5IU:5-IODO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>5IU</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase DNA topoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.2 5.99.1.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1a31| PDB=1a31 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a31 OCA], [http://www.ebi.ac.uk/pdbsum/1a31 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a31 RCSB]</span>
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}}
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'''HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX'''
'''HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX'''
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[[Category: Redinbo, M R.]]
[[Category: Redinbo, M R.]]
[[Category: Stewart, L.]]
[[Category: Stewart, L.]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: topoisomerase i]]
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[[Category: Topoisomerase i]]
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[[Category: topoisomerase i/dna]]
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[[Category: Topoisomerase i/dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:44:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:32:16 2008''
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Revision as of 06:44, 2 May 2008

Image:1a31.gif

Template:STRUCTURE 1a31

HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX


Overview

Topoisomerases I promote the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination. The crystal structures at 2.1 and 2.5 angstrom resolution of reconstituted human topoisomerase I comprising the core and carboxyl-terminal domains in covalent and noncovalent complexes with 22-base pair DNA duplexes reveal an enzyme that "clamps" around essentially B-form DNA. The core domain and the first eight residues of the carboxyl-terminal domain of the enzyme, including the active-site nucleophile tyrosine-723, share significant structural similarity with the bacteriophage family of DNA integrases. A binding mode for the anticancer drug camptothecin is proposed on the basis of chemical and biochemical information combined with these three-dimensional structures of topoisomerase I-DNA complexes.

About this Structure

1A31 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1A31 with [Topoisomerases]. Full crystallographic information is available from OCA.

Reference

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA., Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG, Science. 1998 Mar 6;279(5356):1504-13. PMID:9488644 Page seeded by OCA on Fri May 2 09:44:05 2008

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OCA

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