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5e0j
From Proteopedia
(Difference between revisions)
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==1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor== | ==1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor== | ||
| - | <StructureSection load='5e0j' size='340' side='right' caption='[[5e0j]], [[Resolution|resolution]] 1.20Å' scene=''> | + | <StructureSection load='5e0j' size='340' side='right'caption='[[5e0j]], [[Resolution|resolution]] 1.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5e0j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E0J FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5e0j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hu/nv/nv/1968/us Hu/nv/nv/1968/us]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E0J FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5LJ:(PHENYLMETHYL)+~{N}-[(12~{S},15~{S},18~{S})-15-(CYCLOHEXYLMETHYL)-12-(HYDROXYMETHYL)-9,14,17-TRIS(OXIDANYLIDENE)-1,8,13,16,21,22-HEXAZABICYCLO[18.2.1]TRICOSA-20(23),21-DIEN-18-YL]CARBAMATE'>5LJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5LJ:(PHENYLMETHYL)+~{N}-[(12~{S},15~{S},18~{S})-15-(CYCLOHEXYLMETHYL)-12-(HYDROXYMETHYL)-9,14,17-TRIS(OXIDANYLIDENE)-1,8,13,16,21,22-HEXAZABICYCLO[18.2.1]TRICOSA-20(23),21-DIEN-18-YL]CARBAMATE'>5LJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e0g|5e0g]], [[5e0h|5e0h]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e0g|5e0g]], [[5e0h|5e0h]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=524364 Hu/NV/NV/1968/US])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calicivirin Calicivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.66 3.4.22.66] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calicivirin Calicivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.66 3.4.22.66] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0j OCA], [http://pdbe.org/5e0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0j RCSB], [http://www.ebi.ac.uk/pdbsum/5e0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0j ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0j OCA], [http://pdbe.org/5e0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0j RCSB], [http://www.ebi.ac.uk/pdbsum/5e0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0j ProSAT]</span></td></tr> | ||
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==See Also== | ==See Also== | ||
*[[SARS Coronavirus Main Proteinase|SARS Coronavirus Main Proteinase]] | *[[SARS Coronavirus Main Proteinase|SARS Coronavirus Main Proteinase]] | ||
| - | *[[ | + | *[[Virus protease|Virus protease]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Calicivirin]] | [[Category: Calicivirin]] | ||
| + | [[Category: Hu/nv/nv/1968/us]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Alliston, K R]] | [[Category: Alliston, K R]] | ||
[[Category: Battaile, K P]] | [[Category: Battaile, K P]] | ||
Revision as of 16:05, 11 December 2019
1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor
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Categories: Calicivirin | Hu/nv/nv/1968/us | Large Structures | Alliston, K R | Battaile, K P | Chang, K O | Damalanka, V C | Groutas, W C | Kankanamalage, A C.G | Kim, Y | Lovell, S | Lushington, G H | Mehzabeen, N | Weerawarna, P M | Antiviral inhibitor | Cell permeable | Norovirus | Norwalk virus | Protease | Protease-protease inhibitor complex | Triazole macrocyclic inhibitor
