5lzu
From Proteopedia
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==Structure of the mammalian ribosomal termination complex with accommodated eRF1== | ==Structure of the mammalian ribosomal termination complex with accommodated eRF1== | ||
| - | <StructureSection load='5lzu' size='340' side='right' caption='[[5lzu]], [[Resolution|resolution]] 3.75Å' scene=''> | + | <StructureSection load='5lzu' size='340' side='right'caption='[[5lzu]], [[Resolution|resolution]] 3.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5lzu]] is a 85 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZU FirstGlance]. <br> | <table><tr><td colspan='2'>[[5lzu]] is a 85 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZU FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzu OCA], [http://pdbe.org/5lzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzu RCSB], [http://www.ebi.ac.uk/pdbsum/5lzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzu ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzu OCA], [http://pdbe.org/5lzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzu RCSB], [http://www.ebi.ac.uk/pdbsum/5lzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | {{Large structure}} | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122] [[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> | [[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122] [[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: European rabbit]] | [[Category: European rabbit]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Brown, A]] | [[Category: Brown, A]] | ||
Revision as of 16:37, 11 December 2019
Structure of the mammalian ribosomal termination complex with accommodated eRF1
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