5lzv
From Proteopedia
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==Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.== | ==Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.== | ||
| - | <StructureSection load='5lzv' size='340' side='right' caption='[[5lzv]], [[Resolution|resolution]] 3.35Å' scene=''> | + | <StructureSection load='5lzv' size='340' side='right'caption='[[5lzv]], [[Resolution|resolution]] 3.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5lzv]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZV FirstGlance]. <br> | <table><tr><td colspan='2'>[[5lzv]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZV FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzv OCA], [http://pdbe.org/5lzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzv RCSB], [http://www.ebi.ac.uk/pdbsum/5lzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzv ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzv OCA], [http://pdbe.org/5lzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzv RCSB], [http://www.ebi.ac.uk/pdbsum/5lzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | {{Large structure}} | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122] | [[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: European rabbit]] | [[Category: European rabbit]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Brown, A]] | [[Category: Brown, A]] | ||
Revision as of 16:37, 11 December 2019
Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.
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