1a36

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[[Image:1a36.gif|left|200px]]
[[Image:1a36.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1a36 |SIZE=350|CAPTION= <scene name='initialview01'>1a36</scene>, resolution 2.800&Aring;
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The line below this paragraph, containing "STRUCTURE_1a36", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase DNA topoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.2 5.99.1.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1a36| PDB=1a36 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a36 OCA], [http://www.ebi.ac.uk/pdbsum/1a36 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a36 RCSB]</span>
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}}
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'''TOPOISOMERASE I/DNA COMPLEX'''
'''TOPOISOMERASE I/DNA COMPLEX'''
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[[Category: Redinbo, M R.]]
[[Category: Redinbo, M R.]]
[[Category: Stewart, L.]]
[[Category: Stewart, L.]]
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[[Category: complex (isomerase/dna)]]
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[[Category: Dna]]
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[[Category: dna]]
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[[Category: Topoisomerase i]]
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[[Category: topoisomerase i]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:44:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:32:15 2008''
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Revision as of 06:44, 2 May 2008

Image:1a36.gif


PDB ID 1a36

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1a36, resolution 2.80Å ()
Activity: DNA topoisomerase, with EC number 5.99.1.2
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



TOPOISOMERASE I/DNA COMPLEX


Overview

The three-dimensional structure of a 70-kilodalton amino terminally truncated form of human topoisomerase I in complex with a 22-base pair duplex oligonucleotide, determined to a resolution of 2.8 angstroms, reveals all of the structural elements of the enzyme that contact DNA. The linker region that connects the central core of the enzyme to the carboxyl-terminal domain assumes a coiled-coil configuration and protrudes away from the remainder of the enzyme. The positively charged DNA-proximal surface of the linker makes only a few contacts with the DNA downstream of the cleavage site. In combination with the crystal structures of the reconstituted human topoisomerase I before and after DNA cleavage, this information suggests which amino acid residues are involved in catalyzing phosphodiester bond breakage and religation. The structures also lead to the proposal that the topoisomerization step occurs by a mechanism termed "controlled rotation."

About this Structure

1A36 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1A36 with [Topoisomerases]. Full crystallographic information is available from OCA.

Reference

A model for the mechanism of human topoisomerase I., Stewart L, Redinbo MR, Qiu X, Hol WG, Champoux JJ, Science. 1998 Mar 6;279(5356):1534-41. PMID:9488652 Page seeded by OCA on Fri May 2 09:44:33 2008

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OCA

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