6kry
From Proteopedia
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<StructureSection load='6kry' size='340' side='right'caption='[[6kry]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='6kry' size='340' side='right'caption='[[6kry]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6kry]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KRY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6kry]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KRY FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kry OCA], [http://pdbe.org/6kry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kry RCSB], [http://www.ebi.ac.uk/pdbsum/6kry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kry ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sen, ERS072840_00070, NCTC7878_02454 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kry OCA], [http://pdbe.org/6kry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kry RCSB], [http://www.ebi.ac.uk/pdbsum/6kry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kry ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Staphylococcus aureus strains produce a unique family of immunostimulatory exotoxins termed as bacterial superantigens (SAgs), which cross-link major histocompatibility complex class II (MHC II) molecule and T-cell receptor (TCR) to stimulate large numbers of T cells at extremely low concentrations. SAgs are associated with food poisoning and toxic shock syndrome. To date, 26 genetically distinct staphylococcal SAgs have been reported. This study reports the first X-ray structure of newly characterized staphylococcal enterotoxin N (SEN). SEN possesses the classical two domain architecture that includes an N-terminal oligonucleotide-binding fold and a C-terminal beta-grasp domain. Amino acid and structure alignments revealed that several critical amino acids that are proposed to be responsible for MHC II and TCR molecule engagements are variable in SEN, suggesting that SEN may adopt a different binding mode to its cellular receptors. This work helps better understand the mechanisms of action of SAgs. | ||
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| + | Structure of Staphylococcal Enterotoxin N: Implications for Binding Properties to Its Cellular Proteins.,Zeng C, Liu Z, Han Z Int J Mol Sci. 2019 Nov 25;20(23). pii: ijms20235921. doi: 10.3390/ijms20235921. PMID:31775346<ref>PMID:31775346</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6kry" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 18:36, 11 December 2019
Sructure of staphylococcal enterotoxin SEN
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