1a3o

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[[Image:1a3o.gif|left|200px]]
[[Image:1a3o.gif|left|200px]]
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{{Structure
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|PDB= 1a3o |SIZE=350|CAPTION= <scene name='initialview01'>1a3o</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1a3o", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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|ACTIVITY=
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|GENE=
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{{STRUCTURE_1a3o| PDB=1a3o | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3o OCA], [http://www.ebi.ac.uk/pdbsum/1a3o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a3o RCSB]</span>
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'''ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN'''
'''ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN'''
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[[Category: Tame, J.]]
[[Category: Tame, J.]]
[[Category: Vallone, B.]]
[[Category: Vallone, B.]]
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[[Category: erythrocyte]]
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[[Category: Erythrocyte]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: oxygen transport]]
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[[Category: Oxygen transport]]
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[[Category: respiratory protein]]
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[[Category: Respiratory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:45:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:32:38 2008''
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Revision as of 06:45, 2 May 2008

Image:1a3o.gif

Template:STRUCTURE 1a3o

ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN


Overview

The structures of deoxy human haemoglobin and an artificial mutant (Tyralpha42-->His) have been solved at 120 K. While overall agreement between these structures and others in the PDB is very good, certain side chains are found to be shifted, absent from the electron-density map or in different rotamers. Non-crystallographic symmetry (NCS) is very well obeyed in the native protein, but not around the site of the changed residue in the mutant. NCS is also not obeyed by the water molecule invariably found in the alpha-chain haem pocket in room-temperature crystal structures of haemoglobin. At 120 K, this water molecule disappears from one alpha chain in the asymmetric unit but not the other.

About this Structure

1A3O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structures of deoxy human haemoglobin and the mutant Hb Tyralpha42His at 120 K., Tame JR, Vallone B, Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):805-11. PMID:10930827 Page seeded by OCA on Fri May 2 09:45:55 2008

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