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1dei

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Revision as of 19:26, 11 December 2019

DESHEPTAPEPTIDE (B24-B30) INSULIN

Structural highlights

1dei is a 4 chain structure with sequence from Pig. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Publication Abstract from PubMed

The crystal structure of desheptapeptide (B24-B30) insulin (DHPI), a virtually inactive analog of insulin, was determined at 1.6 A resolution. In the refined structure model, DHPI retains three alpha-helices (A1-A8, A12-A18, and B9-B19) as its structural framework, while great conformational changes occur in the N and C termini of B-chain. The beta-turn, which lies in B20-B30 in insulin and insulin analogs with high potency, no longer exists in DHPI. Relative motion is observed among the three alpha-helices, each as a rigid functional group. In contrast, a region covering B5-B6 and A6-A11 exhibits a relatively stable conformation. We interpret our results as identifying: (i) the importance of beta-turn in determining the receptor-binding potency of insulin and (ii) a leading role of PheB24 in maintaining the beta-turn structure.

Crystal structure of desheptapeptide(B24-B30)insulin at 1.6 A resolution: implications for receptor binding.,Bao SJ, Xie DL, Zhang JP, Chang WR, Liang DC Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2975-80. PMID:9096331^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bao SJ, Xie DL, Zhang JP, Chang WR, Liang DC. Crystal structure of desheptapeptide(B24-B30)insulin at 1.6 A resolution: implications for receptor binding. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2975-80. PMID:9096331

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dei"

@@ Line 1: / Line 1: @@
 ==DESHEPTAPEPTIDE (B24-B30) INSULIN==
-<StructureSection load='1dei' size='340' side='right' caption='[[1dei]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+<StructureSection load='1dei' size='340' side='right'caption='[[1dei]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1dei]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DEI FirstGlance]. <br>
@@ Line 19: / Line 19: @@
 ==See Also==
-*[[Molecular Playground/Insulin|Molecular Playground/Insulin]]
+*[[Insulin 3D Structures|Insulin 3D Structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Pig]]
 [[Category: Bao, S J]]

1dei

From Proteopedia

Revision as of 19:26, 11 December 2019

DESHEPTAPEPTIDE (B24-B30) INSULIN

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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