Retinoid X receptor
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of retinoid X receptor== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Retinoid X receptor α | ||
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| - | **[[3nsp]], [[6hn6]], [[1g1u]] - hRXR LBD – human<br /> | ||
| - | **[[1rxr]] – hRXR DBD (mutant) – NMR<br /> | ||
| - | **[[2q60]] – RXR LBD – ''Polyandrocarpa misakiensis''<br /> | ||
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| - | *Retinoid X receptor α binary complex | ||
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| - | **[[4cn2]], [[4cn3]], [[4cn5]], [[4cn7]], [[1by4]], [[6fbr]], [[6fbq]] - hRXR DBD + DNA <br /> | ||
| - | **[[1g5y]], [[4zhs]] - hRXR LBD + retinoid<br /> | ||
| - | **[[1fby]] - hRXR LBD + 9-''cis'' retinoic acid<br /> | ||
| - | **[[3nsq]] - hRXR LBD + antagonist<br /> | ||
| - | **[[5zqu]] - hRXR LBD + naphthalene derivative <br /> | ||
| - | **[[6jno]] - hRXR LBD + ligand<br /> | ||
| - | **[[3fug]], [[5mk4]] - hRXR LBD + NCOA2 peptide<br /> | ||
| - | **[[3fc6]] – hRXR LBD + NR1H3 protein<br /> | ||
| - | **[[3r29]] - hRXR LBD + corepressor peptide SMRT2<br /> | ||
| - | **[[4n5g]], [[4n8r]], [[5tbp]] - hRXR LBD + modulator <br /> | ||
| - | **[[4ozr]], [[4ozt]] - hRXR LBD + ecdysone receptor <br /> | ||
| - | **[[4j5w]] - hRXR LBD + orphan nuclear receptor PXR<br /> | ||
| - | **[[1dkf]] – mRXR LBD + mRAR LBD – mouse<br /> | ||
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| - | *Retinoid X receptor α ternary complex | ||
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| - | **[[1dsz]] - hRXR LBD + hRAR LBD + DNA<br /> | ||
| - | **[[3a9e]] - hRXR LBD + hRAR LBD + NCOA2 peptide<br /> | ||
| - | **[[3r2a]] - hRXR LBD + corepressor peptide SMRT2 + antagonist<br /> | ||
| - | **[[3h0a]], [[1fm6]], [[1fm9]], [[1k74]], [[5ji0]] - hRXR LBD + PPAR-γ + 9-''cis'' retinoic acid + NCOA2 peptide<br /> | ||
| - | **[[1rdt]] - hRXR LBD + PPAR-γ + NCOA2 peptide<br /> | ||
| - | **[[3oap]], [[4zhs]] - hRXR LBD + 9-''cis'' retinoic acid + NCOA2 peptide<br /> | ||
| - | **[[5mmw]], [[5mku]], [[5mkj]], [[5mj5]] - hRXR LBD + honokiol derivative + peptide<br /> | ||
| - | **[[3ozj]] - hRXR LBD + bigelovin + NCOA2 peptide<br /> | ||
| - | **[[3pcu]] - hRXR LBD + rutamarin + NCOA2 peptide<br /> | ||
| - | **[[2zxz]], [[2zy0]], [[3r5m]], [[1mzn]], [[1mv9]], [[1mvc]], [[4k4j]], [[4k6i]], [[4m8e]], [[4m8h]], [[5lyq]] - hRXR LBD + agonist + NCOA2 peptide<br /> | ||
| - | **[[2acl]] - hRXR LBD + agonist + oxysterols receptor α<br /> | ||
| - | **[[6sjm]] - hRXR LBD + biphenyl + NCOA2 peptide<br /> | ||
| - | **[[3kwy]] - hRXR LBD + triphenyltin + NCOA2 peptide<br /> | ||
| - | **[[3e94]] - hRXR LBD + tributylin + NCOA2 peptide<br /> | ||
| - | **[[2p1t]], [[2p1u]], [[2p1v]], [[4rfw]], [[4rmc]], [[4rme]], [[4rmd]] - hRXR LBD + retinoid + NCOA2 peptide<br /> | ||
| - | **[[5ec9]] - hRXR LBD + coactivator TIF2 peptide + activator<br /> | ||
| - | **[[4oc7]] - hRXR LBD + acrylic acid derivative + NCOA2 peptide<br /> | ||
| - | **[[5ec9]] - hRXR LBD + benzofuran derivative + NCOA2 peptide<br /> | ||
| - | **[[6sti]] - hRXR LBD + naphthalene derivative + NCOA2 peptide<br /> | ||
| - | **[[4poh]], [[4poj]], [[4pp3]], [[4pp5]] - hRXR LBD + trienoic acid derivative + NCOA2 peptide<br /> | ||
| - | **[[1xls]] - hRXR LBD (mutant) + orphan nuclear receptor NR1I3 + NCOA2 peptide<br /> | ||
| - | **[[4j5x]] - hRXR LBD + orphan nuclear receptor PXR + phosphonic acid derivative<br /> | ||
| - | **[[1r0n]], [[1ynw]] - hRXR DBD + DR3 response element + vitamin D3 receptor <br /> | ||
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| - | *Retinoid X receptor α quaternary complex | ||
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| - | **[[3dzu]], [[3dzy]], [[3e00]] - hRXR LBD + PPAR-γ + 9-''cis'' retinoic acid + NCOA2 peptide + DNA<br /> | ||
| - | **[[5uan]] - hRXR LBD + RAR + 9-cis retinoic acid + NCOA2 peptide + DNA<br /> | ||
| - | **[[5z12]] - hRXR LBD + 9-cis retinoic acid + NCOA2 peptide + bile acid receptor<br /> | ||
| - | **[[6a60]], [[6a5z]] - hRXR LBD + 9-cis retinoic acid + oxazol derivative + NCOA1 peptide + bile acid receptor<br /> | ||
| - | **[[6a5y]] - hRXR LBD + 9-cis retinoic acid + thiazol derivative + NCOA1 peptide + bile acid receptor<br /> | ||
| - | **[[4zo1]] - hRXR + NCOA2 peptide + thyroid hormone receptor β<br /> | ||
| - | **[[3uvv]] - hRXR LBD + 9-''cis'' retinoic acid + thyronine + thyroid hormone receptor α<br /> | ||
| - | **[[4zo1]] - hRXR LBD + NCOA2 peptide + thyroid hormone + thyroid hormone receptor β<br /> | ||
| - | **[[3fal]] - hRXR LBD + modulator + oxysterols receptor α + 9-''cis'' retinoic acid<br /> | ||
| - | **[[1xv9]] - hRXR LBD + orphan nuclear receptor NR1I3 + pregnane + NCOA2 peptide<br /> | ||
| - | **[[1xvp]] - hRXR LBD + orphan nuclear receptor NR1I3 + CITCO + NCOA2 peptide<br /> | ||
| - | **[[4nqa]] - hRXR DBD + DR4 response element + liver X nuclear receptor + NCOA2 peptide <br /> | ||
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| - | *Retinoid X receptor β | ||
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| - | **[[1uhl]] - hRXR LBD + oxysterols receptor α + NCOA2 peptide<br /> | ||
| - | **[[1h9u]] – hRXR LBD + agonist<br /> | ||
| - | **[[5hjp]], [[5i4v]] - hRXR LBD + oxysterols receptor LXR-β + agonist<br /> | ||
| - | **[[5kyj]], [[5kya]] - hRXR LBD (mutant) + oxysterols receptor LXR-β + modulator <br /> | ||
| - | **[[1xdk]] - mRXR LBD + mRAR LBD + thyroid receptor associated protein<br /> | ||
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| - | *Retinoid X receptor γ | ||
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| - | **[[2gl8]] – hRXR LBD | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:23, 12 December 2019
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References
- ↑ Dawson MI, Xia Z. The retinoid X receptors and their ligands. Biochim Biophys Acta. 2012 Jan;1821(1):21-56. doi: 10.1016/j.bbalip.2011.09.014. , Epub 2011 Oct 1. PMID:22020178 doi:http://dx.doi.org/10.1016/j.bbalip.2011.09.014
- ↑ Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ. Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. Mol Pharmacol. 2004 Mar;65(3):550-7. PMID:14978233 doi:http://dx.doi.org/10.1124/mol.65.3.550
- ↑ Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Perez E, de Lera AR, Chambon P, Krezel W. Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice. Biol Psychiatry. 2011 Apr 15;69(8):788-94. doi: 10.1016/j.biopsych.2010.12.017., Epub 2011 Feb 21. PMID:21334601 doi:http://dx.doi.org/10.1016/j.biopsych.2010.12.017
- ↑ Natrajan MS, de la Fuente AG, Crawford AH, Linehan E, Nunez V, Johnson KR, Wu T, Fitzgerald DC, Ricote M, Bielekova B, Franklin RJ. Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain. 2015 Dec;138(Pt 12):3581-97. doi: 10.1093/brain/awv289. Epub 2015 Oct 12. PMID:26463675 doi:http://dx.doi.org/10.1093/brain/awv289
- ↑ Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D. Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. EMBO J. 2000 Jun 1;19(11):2592-601. PMID:10835357 doi:10.1093/emboj/19.11.2592
