1a41

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[[Image:1a41.gif|left|200px]]
[[Image:1a41.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1a41 |SIZE=350|CAPTION= <scene name='initialview01'>1a41</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1a41", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase DNA topoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.2 5.99.1.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1a41| PDB=1a41 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a41 OCA], [http://www.ebi.ac.uk/pdbsum/1a41 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a41 RCSB]</span>
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}}
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'''TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS'''
'''TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS'''
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[[Category: Pavletich, N.]]
[[Category: Pavletich, N.]]
[[Category: Shuman, S.]]
[[Category: Shuman, S.]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: type 1b topoisomerase]]
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[[Category: Type 1b topoisomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:46:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:32:46 2008''
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Revision as of 06:46, 2 May 2008

Image:1a41.gif

Template:STRUCTURE 1a41

TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS


Overview

Vaccinia DNA topoisomerase breaks and rejoins DNA strands through a DNA-(3'-phosphotyrosyl)-enzyme intermediate. A C-terminal catalytic domain, Topo(81-314), suffices for transesterification chemistry. The domain contains a constellation of five amino acids, conserved in all eukaryotic type IB topoisomerases, that catalyzes attack of the tyrosine nucleophile on the scissile phosphate. The structure of the catalytic domain, consisting of ten alpha helices and a three-strand beta sheet, resembles the catalytic domains of site-specific recombinases that act via a topoisomerase IB-like mechanism. The topoisomerase catalytic pentad is conserved in the tertiary structures of the recombinases despite scant sequence similarity overall. This implies that the catalytic domains of type IB topoisomerases and recombinases derive from a common ancestral strand transferase.

About this Structure

1A41 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases., Cheng C, Kussie P, Pavletich N, Shuman S, Cell. 1998 Mar 20;92(6):841-50. PMID:9529259 Page seeded by OCA on Fri May 2 09:46:46 2008

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