5qiz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0103080== | |
| - | + | <StructureSection load='5qiz' size='340' side='right'caption='[[5qiz]], [[Resolution|resolution]] 1.63Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5qiz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QIZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J64:N-[(5-chlorothiophen-2-yl)methyl]acetamide'>J64</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qiz OCA], [http://pdbe.org/5qiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qiz RCSB], [http://www.ebi.ac.uk/pdbsum/5qiz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qiz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ubiquitinyl hydrolase 1]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Bradley, A R]] | ||
| + | [[Category: Brandao-Neto, J]] | ||
[[Category: Collins, P]] | [[Category: Collins, P]] | ||
| - | [[Category: | + | [[Category: Delft, F von]] |
| - | [[Category: | + | [[Category: Douangamath, A]] |
| - | + | ||
| - | + | ||
[[Category: Edwards, A]] | [[Category: Edwards, A]] | ||
| - | [[Category: Douangamath, A]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
| + | [[Category: London, N]] | ||
[[Category: Resnick, E]] | [[Category: Resnick, E]] | ||
| - | [[Category: Von Delft, F]] | ||
[[Category: Sethi, R]] | [[Category: Sethi, R]] | ||
| - | [[Category: | + | [[Category: Talon, R]] |
| - | [[Category: | + | [[Category: Deubiquitinating enzyme otub2]] |
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Protease otub2]] | ||
| + | [[Category: Sgc - diamond i04-1 fragment screening]] | ||
| + | [[Category: Xchemexplorer]] | ||
Revision as of 07:35, 18 December 2019
Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0103080
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Categories: Large Structures | Ubiquitinyl hydrolase 1 | Arrowsmith, C H | Bountra, C | Bradley, A R | Brandao-Neto, J | Collins, P | Delft, F von | Douangamath, A | Edwards, A | Krojer, T | London, N | Resnick, E | Sethi, R | Talon, R | Deubiquitinating enzyme otub2 | Hydrolase-hydrolase inhibitor complex | Protease otub2 | Sgc - diamond i04-1 fragment screening | Xchemexplorer
