6ea4
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor== | |
| - | + | <StructureSection load='6ea4' size='340' side='right'caption='[[6ea4]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ea4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EA4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=J2G:4-methoxy-3-{[2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl]sulfamoyl}benzoic+acid'>J2G</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ea4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ea4 OCA], [http://pdbe.org/6ea4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ea4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ea4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ea4 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ERAP2_HUMAN ERAP2_HUMAN]] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.<ref>PMID:12799365</ref> <ref>PMID:15908954</ref> <ref>PMID:16286653</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Maben, Z]] | [[Category: Maben, Z]] | ||
| - | [[Category: Stern, L | + | [[Category: Stern, L J]] |
| + | [[Category: Aminopeptidase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-inhibitor complex]] | ||
| + | [[Category: Immunity]] | ||
| + | [[Category: Inhibitor]] | ||
Revision as of 07:36, 18 December 2019
ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor
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