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6jky

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'''Unreleased structure'''
 
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The entry 6jky is ON HOLD until Mar 03 2021
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==Crystal structure of MvcA-UBE2N-Ub complex form Legionella pneumophila==
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<StructureSection load='6jky' size='340' side='right'caption='[[6jky]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jky]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JKY FirstGlance]. <br>
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Description:
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/E2_ubiquitin-conjugating_enzyme E2 ubiquitin-conjugating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.23 2.3.2.23] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jky OCA], [http://pdbe.org/6jky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jky RCSB], [http://www.ebi.ac.uk/pdbsum/6jky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jky ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/UBE2N_HUMAN UBE2N_HUMAN]] The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity).<ref>PMID:10089880</ref> <ref>PMID:14562038</ref> <ref>PMID:19269966</ref> <ref>PMID:20061386</ref> <ref>PMID:21512573</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: E2 ubiquitin-conjugating enzyme]]
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[[Category: Large Structures]]
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[[Category: Guan, H]]
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[[Category: Ouyang, S Y]]
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[[Category: Legionella pneumophila effect factor complex]]
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[[Category: Signaling protein]]

Revision as of 07:41, 18 December 2019

Crystal structure of MvcA-UBE2N-Ub complex form Legionella pneumophila

PDB ID 6jky

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