6rhv
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH (LukH K319A mutant)== | |
| - | + | <StructureSection load='6rhv' size='340' side='right'caption='[[6rhv]], [[Resolution|resolution]] 2.29Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6rhv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RHV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rhv OCA], [http://pdbe.org/6rhv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rhv RCSB], [http://www.ebi.ac.uk/pdbsum/6rhv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rhv ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ITAM_MOUSE ITAM_MOUSE]] Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038).[UniProtKB:P11215]<ref>PMID:18685038</ref> <ref>PMID:8986723</ref> <ref>PMID:9382884</ref> <ref>PMID:9862668</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Badarau, A]] | ||
| + | [[Category: Djinovic-Carugo, K]] | ||
| + | [[Category: Milic, D]] | ||
| + | [[Category: Trstenjak, N]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Leukocidin]] | ||
| + | [[Category: Octamer]] | ||
| + | [[Category: Pore-forming toxin]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 07:50, 18 December 2019
Crystal structure of mouse CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH (LukH K319A mutant)
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