1a4f
From Proteopedia
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'''BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)''' | '''BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)''' | ||
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[[Category: Gu, X.]] | [[Category: Gu, X.]] | ||
[[Category: Zhang, J.]] | [[Category: Zhang, J.]] | ||
| - | [[Category: | + | [[Category: Erythrocyte]] |
| - | [[Category: | + | [[Category: Heme]] |
| - | [[Category: | + | [[Category: Oxygen transport]] |
| - | [[Category: | + | [[Category: Respiratory protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:47:51 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:47, 2 May 2008
BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)
Overview
We have determined the crystal structure of bar-headed goose haemoglobin in the oxy form to a resolution of 2.0 A. The R-factor of the model is 19.8%. The structure is similar to human HbA, but contacts between the subunits show slightly altered packing of the tetramer. Bar-headed goose blood shows a greatly elevated oxygen affinity compared to closely related species of geese. This is apparently due to a single proline to alanine mutation at the alpha 1 beta 1 interface which destabilises the T state of the protein. The beta chain N and C termini are well-localized, and together with other neighbouring basic groups they form a strongly positively charged groove at the entrance to the central cavity around the molecular dyad. The well-ordered conformation and the three-dimensional distribution of positive charges clearly indicate this area to be the inositol pentaphosphate binding site of bird haemoglobins.
About this Structure
1A4F is a Protein complex structure of sequences from Anser indicus. Full crystallographic information is available from OCA.
Reference
The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)., Zhang J, Hua Z, Tame JR, Lu G, Zhang R, Gu X, J Mol Biol. 1996 Jan 26;255(3):484-93. PMID:8568892 Page seeded by OCA on Fri May 2 09:47:51 2008
