4ydr
From Proteopedia
(Difference between revisions)
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==Crystal structure of oxidized homoserine dehydrogenase of Sulfolobus tokodaii== | ==Crystal structure of oxidized homoserine dehydrogenase of Sulfolobus tokodaii== | ||
| - | <StructureSection load='4ydr' size='340' side='right' caption='[[4ydr]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='4ydr' size='340' side='right'caption='[[4ydr]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ydr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YDR FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ydr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YDR FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ydr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ydr OCA], [http://pdbe.org/4ydr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ydr RCSB], [http://www.ebi.ac.uk/pdbsum/4ydr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ydr ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ydr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ydr OCA], [http://pdbe.org/4ydr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ydr RCSB], [http://www.ebi.ac.uk/pdbsum/4ydr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ydr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Homoserine dehydrogenase (HSD; 305 amino acid residues) catalyzes an NAD(P)-dependent reversible reaction between l-homoserine and aspartate 4-semialdehyde and is involved in the aspartate pathway. HSD from the hyperthermophilic archaeon Sulfolobus tokodaii was markedly activated (2.5-fold) by the addition of 0.8 mM dithiothreitol. The crystal structure of the homodimer indicated that the activation was caused by cleavage of the disulfide bond formed between two cysteine residues (C303) in the C-terminal regions of the two subunits. | ||
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| + | Structural insight into activation of homoserine dehydrogenase from the archaeon Sulfolobus tokodaii via reduction.,Tomonaga Y, Kaneko R, Goto M, Ohshima T, Yoshimune K Biochem Biophys Rep. 2015 Jul 15;3:14-17. doi: 10.1016/j.bbrep.2015.07.006., eCollection 2015 Sep. PMID:29124164<ref>PMID:29124164</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4ydr" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homoserine dehydrogenase]] | [[Category: Homoserine dehydrogenase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Sulto]] | [[Category: Sulto]] | ||
[[Category: Goto, M]] | [[Category: Goto, M]] | ||
Revision as of 08:43, 18 December 2019
Crystal structure of oxidized homoserine dehydrogenase of Sulfolobus tokodaii
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