6das

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==Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design==
==Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design==
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<StructureSection load='6das' size='340' side='right' caption='[[6das]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='6das' size='340' side='right'caption='[[6das]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6das]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DAS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6das]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DAS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G2D:N-[(1R)-6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl]-3-methoxy-4-methylbenzamide'>G2D</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G2D:N-[(1R)-6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl]-3-methoxy-4-methylbenzamide'>G2D</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6das FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6das OCA], [http://pdbe.org/6das PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6das RCSB], [http://www.ebi.ac.uk/pdbsum/6das PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6das ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6das FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6das OCA], [http://pdbe.org/6das PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6das RCSB], [http://www.ebi.ac.uk/pdbsum/6das PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6das ProSAT]</span></td></tr>
</table>
</table>
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</div>
</div>
<div class="pdbe-citations 6das" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6das" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[WD repeat-containing protein|WD repeat-containing protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Fesik, S W]]
[[Category: Fesik, S W]]
[[Category: Phan, J]]
[[Category: Phan, J]]

Revision as of 10:02, 18 December 2019

Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design

PDB ID 6das

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