6oia

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'''Unreleased structure'''
 
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The entry 6oia is ON HOLD until Paper Publication
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==(1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase==
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<StructureSection load='6oia' size='340' side='right'caption='[[6oia]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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Authors: Catlin, D.S., Liu, D., Moschitto, M.J., Doubleday, P.F., Kelleher, N., Silverman, R.B.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6oia]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OIA FirstGlance]. <br>
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Description: (1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MQ4:(1S)-3-amino-4-[(2S)-1,1,1-trifluoro-3-oxopropan-2-yl]cyclopent-3-ene-1-carboxylic+acid'>MQ4</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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[[Category: Doubleday, P.F]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
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[[Category: Moschitto, M.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oia OCA], [http://pdbe.org/6oia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oia RCSB], [http://www.ebi.ac.uk/pdbsum/6oia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oia ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN]] Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:[http://omim.org/entry/258870 258870]]. HOGA is a slowly progressive blinding autosomal recessive disorder.<ref>PMID:3375240</ref> <ref>PMID:2793865</ref> <ref>PMID:1612597</ref> <ref>PMID:1737786</ref> <ref>PMID:7887415</ref> <ref>PMID:7668253</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Ornithine aminotransferase]]
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[[Category: Catlin, D S]]
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[[Category: Doubleday, P F]]
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[[Category: Kelleher, N]]
[[Category: Liu, D]]
[[Category: Liu, D]]
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[[Category: Kelleher, N]]
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[[Category: Moschitto, M J]]
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[[Category: Silverman, R.B]]
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[[Category: Silverman, R B]]
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[[Category: Catlin, D.S]]
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[[Category: Transferase]]

Revision as of 12:01, 18 December 2019

(1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase

PDB ID 6oia

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OCA

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