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1a58

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[[Image:1a58.gif|left|200px]]
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{{Structure
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|GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6279 Brugia malayi])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a58 OCA], [http://www.ebi.ac.uk/pdbsum/1a58 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a58 RCSB]</span>
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'''CYCLOPHILIN FROM BRUGIA MALAYI'''
'''CYCLOPHILIN FROM BRUGIA MALAYI'''
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[[Category: Taylor, P.]]
[[Category: Taylor, P.]]
[[Category: Walkinshaw, M D.]]
[[Category: Walkinshaw, M D.]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: ppiase]]
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[[Category: Ppiase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:49:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:33:35 2008''
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Revision as of 06:49, 2 May 2008

Image:1a58.gif

Template:STRUCTURE 1a58

CYCLOPHILIN FROM BRUGIA MALAYI


Overview

A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.

About this Structure

1A58 is a Single protein structure of sequence from Brugia malayi. Full crystallographic information is available from OCA.

Reference

The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi., Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD, FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:9559680 Page seeded by OCA on Fri May 2 09:49:55 2008

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