1a65

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[[Image:1a65.jpg|left|200px]]
[[Image:1a65.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1a65 |SIZE=350|CAPTION= <scene name='initialview01'>1a65</scene>, resolution 2.23&Aring;
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The line below this paragraph, containing "STRUCTURE_1a65", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=T1:Type+1+Cu+Binding+Site'>T1</scene> and <scene name='pdbsite=T3:Type+3+Cu+Binding+Site'>T3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Laccase Laccase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1a65| PDB=1a65 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a65 OCA], [http://www.ebi.ac.uk/pdbsum/1a65 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a65 RCSB]</span>
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}}
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'''TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS'''
'''TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS'''
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[[Category: Brzozowski, W.]]
[[Category: Brzozowski, W.]]
[[Category: Ducros, V.]]
[[Category: Ducros, V.]]
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[[Category: blue multi-copper oxidase]]
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[[Category: Blue multi-copper oxidase]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: laccase]]
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[[Category: Laccase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: signal]]
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[[Category: Signal]]
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[[Category: type-2 copper depleted]]
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[[Category: Type-2 copper depleted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:52:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:08 2008''
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Revision as of 06:52, 2 May 2008

Image:1a65.jpg

Template:STRUCTURE 1a65

TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS


Overview

Laccase catalyses the oxidation of a variety of organic substrates coupled to the reduction of oxygen to water. It is widely believed to be the simplest representative of the ubiquitous blue multi-copper oxidase family. Laccase is implicated in a wide spectrum of biological activities and, in particular, plays a key role in morphogenesis, development and lignin metabolism in fungi and plants. The structure of laccase from the fungus Coprinus cinereus has been determined by X-ray crystallography at a resolution of 2.2 A. Laccase is a monomer composed of three cupredoxin-like beta-sandwich domains, similar to that found in ascorbate oxidase. In contrast to ascorbate oxidase, however, the mononuclear type-1 Cu site lacks the axial methionine ligand and so exhibits trigonal planar coordination, consistent with its elevated redox potential. Crucially, the structure is trapped in a Cu depleted form in which the putative type-2 Cu atom is completely absent, but in which the remaining type-1 and type-3 Cu sites display full occupancy. Type-2 Cu depletion has unexpected consequences for the coordination of the remaining type-3 Cu atoms.

About this Structure

1A65 is a Single protein structure of sequence from Coprinopsis cinerea. Full crystallographic information is available from OCA.

Reference

Crystal structure of the type-2 Cu depleted laccase from Coprinus cinereus at 2.2 A resolution., Ducros V, Brzozowski AM, Wilson KS, Brown SH, Ostergaard P, Schneider P, Yaver DS, Pedersen AH, Davies GJ, Nat Struct Biol. 1998 Apr;5(4):310-6. PMID:9546223 Page seeded by OCA on Fri May 2 09:52:11 2008

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