6s22

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m (Protected "6s22" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6s22 is ON HOLD
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==Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and FGF23c==
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<StructureSection load='6s22' size='340' side='right'caption='[[6s22]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6s22]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S22 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s22 OCA], [http://pdbe.org/6s22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s22 RCSB], [http://www.ebi.ac.uk/pdbsum/6s22 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s22 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/FGF23_HUMAN FGF23_HUMAN]] Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) [MIM:[http://omim.org/entry/193100 193100]]. ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses.<ref>PMID:11062477</ref> <ref>PMID:11409890</ref> <ref>PMID:16638743</ref> Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:[http://omim.org/entry/211900 211900]]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues.<ref>PMID:15590700</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/FGF23_HUMAN FGF23_HUMAN]] Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.<ref>PMID:11062477</ref> <ref>PMID:11409890</ref> <ref>PMID:15040831</ref> <ref>PMID:16597617</ref> <ref>PMID:18282132</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Bernado, P]]
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[[Category: Ceballos-Laita, L]]
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[[Category: Clausen, H]]
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[[Category: Coelho, H]]
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[[Category: Companon, I]]
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[[Category: Corzana, F]]
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[[Category: Daniel, E J.P]]
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[[Category: Gerken, T A]]
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[[Category: Hansen, L]]
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[[Category: Hermosilla, P]]
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[[Category: Hurtado-Guerrero, R]]
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[[Category: Kato, K]]
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[[Category: Lostao, A]]
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[[Category: Marcelo, F]]
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[[Category: Narimatsu, Y]]
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[[Category: Rivas, M de las]]
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[[Category: Thureau, A]]
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[[Category: Enzyme kinetic]]
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[[Category: Fgf23]]
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[[Category: Galnac-t]]
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[[Category: Galnac-t3]]
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[[Category: Long-range glycosylation preference]]
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[[Category: Molecular dynamic]]
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[[Category: Phosphate homeostasis]]
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[[Category: Specificity]]
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[[Category: Transferase]]

Revision as of 09:16, 25 December 2019

Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and FGF23c

PDB ID 6s22

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