6v2r
From Proteopedia
(Difference between revisions)
m (Protected "6v2r" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866== | |
| - | + | <StructureSection load='6v2r' size='340' side='right'caption='[[6v2r]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6v2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6V2R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5R0:4-~{TERT}-BUTYLBENZOIC+ACID'>5R0</scene>, <scene name='pdbligand=5R5:METHYL+(2~{S})-2-AZANYL-3-OXIDANYL-PROPANOATE'>5R5</scene>, <scene name='pdbligand=ELY:N~6~,N~6~-DIETHYL-L-LYSINE'>ELY</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6v2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v2r OCA], [http://pdbe.org/6v2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v2r RCSB], [http://www.ebi.ac.uk/pdbsum/6v2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v2r ProSAT]</span></td></tr> |
| - | [[Category: Dickson, B | + | </table> |
| - | [[Category: James, L | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/CBX7_HUMAN CBX7_HUMAN]] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:19636380</ref> <ref>PMID:21060834</ref> <ref>PMID:21282530</ref> <ref>PMID:21047797</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Dickson, B M]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Frye, S V]] | ||
| + | [[Category: James, L I]] | ||
| + | [[Category: Liu, Y]] | ||
[[Category: Min, J]] | [[Category: Min, J]] | ||
| - | + | [[Category: Structural genomic]] | |
| - | + | [[Category: Stuckey, J I]] | |
| - | + | ||
| - | [[Category: Structural | + | |
| - | + | ||
| - | [[Category: Stuckey, J | + | |
| - | + | ||
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
| + | [[Category: Walker, J R]] | ||
| + | [[Category: Gene regulation]] | ||
| + | [[Category: Sgc]] | ||
Revision as of 09:23, 25 December 2019
Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866
| |||||||||||
Categories: Large Structures | Arrowsmith, C H | Bountra, C | Dickson, B M | Edwards, A M | Frye, S V | James, L I | Liu, Y | Min, J | Structural genomic | Stuckey, J I | Tempel, W | Walker, J R | Gene regulation | Sgc
