3ul3

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==Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery==
==Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery==
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<StructureSection load='3ul3' size='340' side='right' caption='[[3ul3]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
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<StructureSection load='3ul3' size='340' side='right'caption='[[3ul3]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ul3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UL3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ul3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UL3 FirstGlance]. <br>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ul3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ul3 OCA], [http://pdbe.org/3ul3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ul3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ul3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ul3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ul3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ul3 OCA], [http://pdbe.org/3ul3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ul3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ul3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ul3 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Thioredoxins are vital components of Plasmodium proteome and act as both reducing agents and protein disulfide reductases. The malaria parasite P. falciparum thioredoxin-2 (PfTrx-2) is part of the multi-protein complex embedded within the parasite parasitophorous vacuolar membrane (PVM) which purportedly directs protein secretion. We have characterized structural and enzymatic features of PfTrx-2, and we show that PfTrx-2 adopts a canonical thioredoxin fold but with significant structural differences in its N-terminus. Our confocal localization data suggest distinct PVM residency of PfTrx-2. Based on the crystal structure of PfTrx-2, we screened and tested small molecule drug-like libraries for compounds which target unique structural features of PfTrx-2. Disruption of PfTrx-2 interactions using specific inhibitors may result in a dysfunctional parasite translocon that is rendered unable to secrete pathogenic proteins into hosts. This approach therefore offers a new focus for anti-malarial drug development.
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Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery.,Sharma A, Sharma A, Dixit S, Sharma A Sci Rep. 2011;1:179. doi: 10.1038/srep00179. Epub 2011 Dec 1. PMID:22355694<ref>PMID:22355694</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ul3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thioredoxin|Thioredoxin]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Plaf7]]
[[Category: Plaf7]]
[[Category: Dixit, S]]
[[Category: Dixit, S]]

Revision as of 09:54, 25 December 2019

Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery

PDB ID 3ul3

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