4qkk
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qkk OCA], [http://pdbe.org/4qkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qkk RCSB], [http://www.ebi.ac.uk/pdbsum/4qkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qkk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qkk OCA], [http://pdbe.org/4qkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qkk RCSB], [http://www.ebi.ac.uk/pdbsum/4qkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qkk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The modified base 5-formylcytosine (5fC) was recently identified in mammalian DNA and might be considered to be the 'seventh' base of the genome. This nucleotide has been implicated in active demethylation mediated by the base excision repair enzyme thymine DNA glycosylase. Genomics and proteomics studies have suggested an additional role for 5fC in transcription regulation through chromatin remodeling. Here we propose that 5fC might affect these processes through its effect on DNA conformation. Biophysical and structural analysis revealed that 5fC alters the structure of the DNA double helix and leads to a conformation unique among known DNA structures including those comprising other cytosine modifications. The 1.4-A-resolution X-ray crystal structure of a DNA dodecamer comprising three 5fCpG sites shows how 5fC changes the geometry of the grooves and base pairs associated with the modified base, leading to helical underwinding. | ||
| + | |||
| + | 5-Formylcytosine alters the structure of the DNA double helix.,Raiber EA, Murat P, Chirgadze DY, Beraldi D, Luisi BF, Balasubramanian S Nat Struct Mol Biol. 2015 Jan;22(1):44-49. doi: 10.1038/nsmb.2936. Epub 2014 Dec , 15. PMID:25504322<ref>PMID:25504322</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4qkk" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:16, 25 December 2019
Crystal structure of an oligonucleotide containing 5-formylcytosine
| |||||||||||
