1a6j
From Proteopedia
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'''NITROGEN REGULATORY BACTERIAL PROTEIN IIA-NITROGEN''' | '''NITROGEN REGULATORY BACTERIAL PROTEIN IIA-NITROGEN''' | ||
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The three-dimensional structure of the nitrogen regulatory protein IIANtr from Escherichia coli., Bordo D, van Monfort RL, Pijning T, Kalk KH, Reizer J, Saier MH Jr, Dijkstra BW, J Mol Biol. 1998 May 29;279(1):245-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9636714 9636714] | The three-dimensional structure of the nitrogen regulatory protein IIANtr from Escherichia coli., Bordo D, van Monfort RL, Pijning T, Kalk KH, Reizer J, Saier MH Jr, Dijkstra BW, J Mol Biol. 1998 May 29;279(1):245-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9636714 9636714] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Protein-N(pi)-phosphohistidine--sugar phosphotransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bordo, D.]] | [[Category: Bordo, D.]] | ||
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[[Category: Reizer, J.]] | [[Category: Reizer, J.]] | ||
[[Category: Saier, M H.]] | [[Category: Saier, M H.]] | ||
| - | [[Category: | + | [[Category: Nitrogen regulation]] |
| - | [[Category: | + | [[Category: Phosphotransferase system]] |
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Revision as of 06:53, 2 May 2008
NITROGEN REGULATORY BACTERIAL PROTEIN IIA-NITROGEN
Overview
The bacterial rpoN operon codes for sigma 54, which is the key sigma factor that, under nitrogen starvation conditions, activates the transcription of genes needed to assimilate ammonia and glutamate. The rpoN operon contains several other open reading frames that are cotranscribed with sigma 54. The product of one of these, the 17.9 kDa protein IIANtr, is homologous to IIA proteins of the phosphoenolpyruvate:sugar phosphotransferase (PTS) system. IIANtr influences the transcription of sigma 54-dependent genes through an unknown mechanism and may thereby provide a regulatory link between carbon and nitrogen metabolism. Here we describe the 2.35 A X-ray structure of Escherichia coli IIANtr. It is the first structure of a IIA enzyme from the fructose-mannitol family of the PTS. The enzyme displays a novel fold characterized by a central mixed parallel/anti-parallel beta-sheet surrounded by six alpha-helices. The active site His73 is situated in a shallow depression on the protein surface.
About this Structure
1A6J is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The three-dimensional structure of the nitrogen regulatory protein IIANtr from Escherichia coli., Bordo D, van Monfort RL, Pijning T, Kalk KH, Reizer J, Saier MH Jr, Dijkstra BW, J Mol Biol. 1998 May 29;279(1):245-55. PMID:9636714 Page seeded by OCA on Fri May 2 09:53:22 2008
