1a6q

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[[Image:1a6q.gif|left|200px]]
[[Image:1a6q.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1a6q |SIZE=350|CAPTION= <scene name='initialview01'>1a6q</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1a6q", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=MN2:Mn+2++Binding+Sites'>MN2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1a6q| PDB=1a6q | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6q OCA], [http://www.ebi.ac.uk/pdbsum/1a6q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a6q RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION'''
'''CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION'''
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[[Category: Das, A K.]]
[[Category: Das, A K.]]
[[Category: Helps, N R.]]
[[Category: Helps, N R.]]
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[[Category: catalytic mechanism]]
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[[Category: Catalytic mechanism]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: metalloenzyme]]
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[[Category: Metalloenzyme]]
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[[Category: protein phosphatase 2c]]
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[[Category: Protein phosphatase 2c]]
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[[Category: signal transductuin]]
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[[Category: Signal transductuin]]
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[[Category: x-ray crystallography]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:53:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:28 2008''
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Revision as of 06:53, 2 May 2008

Image:1a6q.gif

Template:STRUCTURE 1a6q

CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION


Overview

Protein phosphatase 2C (PP2C) is a Mn2+- or Mg2+-dependent protein Ser/Thr phosphatase that is essential for regulating cellular stress responses in eukaryotes. The crystal structure of human PP2C reveals a novel protein fold with a catalytic domain composed of a central beta-sandwich that binds two manganese ions, which is surrounded by alpha-helices. Mn2+-bound water molecules at the binuclear metal centre coordinate the phosphate group of the substrate and provide a nucleophile and general acid in the dephosphorylation reaction. Our model presents a framework for understanding not only the classical Mn2+/Mg2+-dependent protein phosphatases but also the sequence-related domains of mitochondrial pyruvate dehydrogenase phosphatase, the Bacillus subtilus phosphatase SpoIIE and a 300-residue domain within yeast adenyl cyclase. The protein architecture and deduced catalytic mechanism are strikingly similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity, suggestive of convergent evolution of protein Ser/Thr phosphatases.

About this Structure

1A6Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution., Das AK, Helps NR, Cohen PT, Barford D, EMBO J. 1996 Dec 16;15(24):6798-809. PMID:9003755 Page seeded by OCA on Fri May 2 09:53:49 2008

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