1a6s
From Proteopedia
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'''M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES''' | '''M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES''' | ||
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[[Category: Wolven, A.]] | [[Category: Wolven, A.]] | ||
[[Category: Zhou, W.]] | [[Category: Zhou, W.]] | ||
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Revision as of 06:54, 2 May 2008
M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES
Overview
A biologically active construct of the retroviral M domain from the avian Rous sarcoma virus is defined and its solution structure described. This M domain is fully active in budding and infectivity without myristylation. In spite of a sequence homology level that suggests no relationship among M domains and the family of matrix proteins in mammalian retroviruses, the conserved structural elements of a central core allow an M domain sequence motif to be described for all retroviruses. The surface of the M domain has a highly clustered positive patch comprised of sequentially distant residues. An analysis of the backbone dynamics, incorporating rotational anisotropy, is used to estimate the thermodynamics of proposed domain oligomerization.
About this Structure
1A6S is a Single protein structure of sequence from Rous sarcoma virus. Full crystallographic information is available from OCA.
Reference
Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus., McDonnell JM, Fushman D, Cahill SM, Zhou W, Wolven A, Wilson CB, Nelle TD, Resh MD, Wills J, Cowburn D, J Mol Biol. 1998 Jun 19;279(4):921-8. PMID:9642071 Page seeded by OCA on Fri May 2 09:54:03 2008
