1a6y

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[[Image:1a6y.gif|left|200px]]
[[Image:1a6y.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1a6y", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=5IU:5-IODO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>5IU</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1a6y| PDB=1a6y | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6y OCA], [http://www.ebi.ac.uk/pdbsum/1a6y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a6y RCSB]</span>
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'''REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX'''
'''REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX'''
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[[Category: Rastinejad, F.]]
[[Category: Rastinejad, F.]]
[[Category: Zhao, Q.]]
[[Category: Zhao, Q.]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: nuclear receptor]]
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[[Category: Nuclear receptor]]
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[[Category: orphan receptor]]
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[[Category: Orphan receptor]]
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[[Category: rev-erb]]
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[[Category: Rev-erb]]
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[[Category: reverb]]
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[[Category: Reverb]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:54:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:44 2008''
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Revision as of 06:54, 2 May 2008

Image:1a6y.gif

Template:STRUCTURE 1a6y

REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX


Overview

The nuclear hormone receptors form the largest known family of transcription factors. The current notion of receptor DNA discrimination, based solely on one major type of hexameric half-site and a highly conserved 66-residue core DNA-binding domain (DBD), does not adequately describe how more than 150 nonsteroid receptors differentiate among response elements. Here, we describe the 2.3 A crystal structure of the DNA-binding region of the orphan receptor RevErb arranged as a tandem homodimer on its optimal response element. The structure reveals the presence of a second major protein-DNA interface adjacent to the classical one involving the half-sites. A sequence comparison of orphan receptors suggests that unique minor-groove interactions involving the receptor hinge regions impart the necessary DNA and dimerization specificity.

About this Structure

1A6Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural elements of an orphan nuclear receptor-DNA complex., Zhao Q, Khorasanizadeh S, Miyoshi Y, Lazar MA, Rastinejad F, Mol Cell. 1998 May;1(6):849-61. PMID:9660968 Page seeded by OCA on Fri May 2 09:54:26 2008

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