1a7h
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1a7h.gif|left|200px]] | [[Image:1a7h.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1a7h", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1a7h| PDB=1a7h | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN''' | '''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN''' | ||
| Line 27: | Line 24: | ||
[[Category: Basak, A K.]] | [[Category: Basak, A K.]] | ||
[[Category: Slingsby, C.]] | [[Category: Slingsby, C.]] | ||
| - | [[Category: | + | [[Category: Eye lens protein]] |
| - | [[Category: | + | [[Category: Eye-lens protein]] |
| - | [[Category: | + | [[Category: Gamma crystallin s]] |
| - | [[Category: | + | [[Category: Multigene family]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:55:47 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:55, 2 May 2008
GAMMA S CRYSTALLIN C-TERMINAL DOMAIN
Overview
The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.
About this Structure
1A7H is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis., Basak AK, Kroone RC, Lubsen NH, Naylor CE, Jaenicke R, Slingsby C, Protein Eng. 1998 May;11(5):337-44. PMID:9681865 Page seeded by OCA on Fri May 2 09:55:47 2008
