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The 6HMM protein is a human poly (ADP-ribose) glycohydrolase. It is an enzyme that will catalyze the hydrolysis of glycosides, here more specifically it will produce a free ADP-ribose. This protein is only present when the DNA is damaged. It influences the damaged chromatin through a derepression on a gene promoter. Consequently this protein is quite interesting for biotechnical applications. Indeed, developing proteins who repair DNA damage is a meaningful goal in research. Moreover, this protein is found in humans, so understanding its structure could have an impact on humans.

Structure

Structural highlights

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Links of PARG with other ligands

Function

The protein is a complex composed of the poly(ADP-ribosyl) glycohydrolase (PARG) and anthraquinone PDD00013907. The post-translational modifications of the PAR protein (poly ADP-ribose) are important for DNA stability. The PARG is used for one of these modifications, the hydrolyzation of specific ribose-ribose bonds present in PAR which leads to the degradation of PAR. PDD00013907 is an anthraquinone which is a polycyclic aromatic hydrocarbon usually used in biopesticides as a pest repellant. Here it is considered as a free ligand (of identification number on PDB: 7JB) that can bind to the PARG creating the protein complex 6HMM.

Post-translational modifications to stabilize DNA

The mechanism of the post-translational modifications

Diseases and Relevance