1a7u

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[[Image:1a7u.jpg|left|200px]]
[[Image:1a7u.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1a7u |SIZE=350|CAPTION= <scene name='initialview01'>1a7u</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1a7u", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CTA:Catalytic+Triad'>CTA</scene> and <scene name='pdbsite=CTB:Catalytic+Triad'>CTB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chloride_peroxidase Chloride peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CPOT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1894 Streptomyces aureofaciens])
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-->
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|DOMAIN=
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{{STRUCTURE_1a7u| PDB=1a7u | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7u OCA], [http://www.ebi.ac.uk/pdbsum/1a7u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a7u RCSB]</span>
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}}
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'''CHLOROPEROXIDASE T'''
'''CHLOROPEROXIDASE T'''
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[[Category: Pelletier, I.]]
[[Category: Pelletier, I.]]
[[Category: Toelzer, S.]]
[[Category: Toelzer, S.]]
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[[Category: alpha/beta hydrolase fold]]
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[[Category: Alpha/beta hydrolase fold]]
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[[Category: haloperoxidase]]
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[[Category: Haloperoxidase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: peroxidase]]
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[[Category: Peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:56:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:35:17 2008''
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Revision as of 06:56, 2 May 2008

Image:1a7u.jpg

Template:STRUCTURE 1a7u

CHLOROPEROXIDASE T


Overview

The structures of cofactor-free haloperoxidases from Streptomyces aureofaciens, Streptomyces lividans, and Pseudomonas fluorescens have been determined at resolutions between 1.9 A and 1.5 A. The structures of two enzymes complexed with benzoate or propionate identify the binding site for the organic acids which are required for the haloperoxidase activity. Based on these complexes and on the structure of an inactive variant, a reaction mechanism is proposed for the halogenation reaction with peroxoacid and hypohalous acid as reaction intermediates. Comparison of the structures suggests that a specific halide binding site is absent in the enzymes but that hydrophobic organic compounds may fit into the active site pocket for halogenation at preferential sites.

About this Structure

1A7U is a Single protein structure of sequence from Streptomyces aureofaciens. Full crystallographic information is available from OCA.

Reference

Structural investigation of the cofactor-free chloroperoxidases., Hofmann B, Tolzer S, Pelletier I, Altenbuchner J, van Pee KH, Hecht HJ, J Mol Biol. 1998 Jun 19;279(4):889-900. PMID:9642069 Page seeded by OCA on Fri May 2 09:56:40 2008

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