| Structural highlights
Disease
[ULK4_HUMAN] Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia.[1]
Function
[ULK4_HUMAN] May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.[2]
References
- ↑ Lang B, Pu J, Hunter I, Liu M, Martin-Granados C, Reilly TJ, Gao GD, Guan ZL, Li WD, Shi YY, He G, He L, Stefansson H, St Clair D, Blackwood DH, McCaig CD, Shen S. Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility. J Cell Sci. 2014 Feb 1;127(Pt 3):630-40. doi: 10.1242/jcs.137604. Epub 2013 Nov, 27. PMID:24284070 doi:http://dx.doi.org/10.1242/jcs.137604
- ↑ Lang B, Pu J, Hunter I, Liu M, Martin-Granados C, Reilly TJ, Gao GD, Guan ZL, Li WD, Shi YY, He G, He L, Stefansson H, St Clair D, Blackwood DH, McCaig CD, Shen S. Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility. J Cell Sci. 2014 Feb 1;127(Pt 3):630-40. doi: 10.1242/jcs.137604. Epub 2013 Nov, 27. PMID:24284070 doi:http://dx.doi.org/10.1242/jcs.137604
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