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6v6c
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Structure of GCP6 in the native human gamma-tubulin ring complex== |
| + | <StructureSection load='6v6c' size='340' side='right'caption='[[6v6c]], [[Resolution|resolution]] 4.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6v6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6V6C FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6v6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v6c OCA], [http://pdbe.org/6v6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v6c RCSB], [http://www.ebi.ac.uk/pdbsum/6v6c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v6c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/GCP6_HUMAN GCP6_HUMAN]] Autosomal recessive chorioretinopathy-microcephaly syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GCP6_HUMAN GCP6_HUMAN]] Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.<ref>PMID:11694571</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The gamma-tubulin ring complex (gamma-TuRC) is an essential regulator of centrosomal and acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo-EM reconstruction of the native human gamma-TuRC at approximately 3.8 A resolution, revealing an asymmetric, cone-shaped structure. Pseudo-atomic models indicate that GCP4, GCP5, and GCP6 form distinct Y-shaped assemblies that structurally mimic GCP2/GCP3 subcomplexes distal to the gamma-TuRC "seam." We also identify an unanticipated structural bridge that includes an actin-like protein and spans the gamma-TuRC lumen. Despite its asymmetric architecture, the gamma-TuRC arranges gamma-tubulins into a helical geometry poised to nucleate microtubules. Diversity in the gamma-TuRC subunits introduces large (>100,000 A(2)) surfaces in the complex that allow for interactions with different regulatory factors. The observed compositional complexity of the gamma-TuRC could self-regulate its assembly into a cone-shaped structure to control microtubule formation across diverse contexts, e.g., within biological condensates or alongside existing filaments. | ||
| - | + | Asymmetric Molecular Architecture of the Human gamma-Tubulin Ring Complex.,Wieczorek M, Urnavicius L, Ti SC, Molloy KR, Chait BT, Kapoor TM Cell. 2019 Dec 13. pii: S0092-8674(19)31369-8. doi: 10.1016/j.cell.2019.12.007. PMID:31862189<ref>PMID:31862189</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6v6c" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chait, B T]] | ||
| + | [[Category: Kapoor, T M]] | ||
| + | [[Category: Molloy, K R]] | ||
| + | [[Category: Ti, S]] | ||
| + | [[Category: Urnavicius, L]] | ||
| + | [[Category: Wieczorek, M]] | ||
| + | [[Category: G-turc]] | ||
| + | [[Category: Gamma-tubulin ring complex]] | ||
| + | [[Category: Gcp]] | ||
| + | [[Category: Gcp6]] | ||
| + | [[Category: Gturc]] | ||
| + | [[Category: Microtubule]] | ||
| + | [[Category: Microtubule nucleation]] | ||
| + | [[Category: Single particle cryo-em structure]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 08:31, 1 January 2020
Structure of GCP6 in the native human gamma-tubulin ring complex
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