1a7x

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[[Image:1a7x.gif|left|200px]]
[[Image:1a7x.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1a7x |SIZE=350|CAPTION= <scene name='initialview01'>1a7x</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1a7x", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FKA:BENZYL-CARBAMIC+ACID+[8-DEETHYL-ASCOMYCIN-8-YL]ETHYL+ESTER'>FKA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1a7x| PDB=1a7x | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7x OCA], [http://www.ebi.ac.uk/pdbsum/1a7x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a7x RCSB]</span>
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}}
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'''FKBP12-FK1012 COMPLEX'''
'''FKBP12-FK1012 COMPLEX'''
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[[Category: Clardy, J.]]
[[Category: Clardy, J.]]
[[Category: Schultz, L W.]]
[[Category: Schultz, L W.]]
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[[Category: immunophilin]]
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[[Category: Immunophilin]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:56:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:35:10 2008''
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Revision as of 06:56, 2 May 2008

Image:1a7x.gif

Template:STRUCTURE 1a7x

FKBP12-FK1012 COMPLEX


Overview

A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.

About this Structure

1A7X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:9871618 Page seeded by OCA on Fri May 2 09:56:53 2008

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