5uys
From Proteopedia
(Difference between revisions)
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==Human steroidogenic cytochrome P450 17A1 with 3alphaOH-5alpha-abiraterone analog== | ==Human steroidogenic cytochrome P450 17A1 with 3alphaOH-5alpha-abiraterone analog== | ||
| - | <StructureSection load='5uys' size='340' side='right' caption='[[5uys]], [[Resolution|resolution]] 2.39Å' scene=''> | + | <StructureSection load='5uys' size='340' side='right'caption='[[5uys]], [[Resolution|resolution]] 2.39Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5uys]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UYS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5uys]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UYS FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8QD:(3alpha,5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-ol'>8QD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8QD:(3alpha,5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-ol'>8QD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nkv|4nkv]], [[4nkw|4nkw]], [[4nkx|4nkx]], [[4nky|4nky]], [[4nkz|4nkz]], [[3ruk|3ruk]], [[3swz|3swz]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nkv|4nkv]], [[4nkw|4nkw]], [[4nkx|4nkx]], [[4nky|4nky]], [[4nkz|4nkz]], [[3ruk|3ruk]], [[3swz|3swz]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP17A1, CYP17, S17AH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uys OCA], [http://pdbe.org/5uys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uys RCSB], [http://www.ebi.ac.uk/pdbsum/5uys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uys ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uys OCA], [http://pdbe.org/5uys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uys RCSB], [http://www.ebi.ac.uk/pdbsum/5uys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uys ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref> | [[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref> | ||
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| + | ==See Also== | ||
| + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Petrunak, E M]] | [[Category: Petrunak, E M]] | ||
[[Category: Scott, E E]] | [[Category: Scott, E E]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Steroidogenic]] | [[Category: Steroidogenic]] | ||
Revision as of 09:24, 1 January 2020
Human steroidogenic cytochrome P450 17A1 with 3alphaOH-5alpha-abiraterone analog
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