6bki
From Proteopedia
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==Crystal structure of T101A variant mouse cathepsin K at 2.94 Angstrom resolution.== | ==Crystal structure of T101A variant mouse cathepsin K at 2.94 Angstrom resolution.== | ||
| - | <StructureSection load='6bki' size='340' side='right' caption='[[6bki]], [[Resolution|resolution]] 2.94Å' scene=''> | + | <StructureSection load='6bki' size='340' side='right'caption='[[6bki]], [[Resolution|resolution]] 2.94Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6bki]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BKI FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6bki]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BKI FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ctsk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bki OCA], [http://pdbe.org/6bki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bki RCSB], [http://www.ebi.ac.uk/pdbsum/6bki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bki ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bki OCA], [http://pdbe.org/6bki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bki RCSB], [http://www.ebi.ac.uk/pdbsum/6bki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bki ProSAT]</span></td></tr> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/CATK_MOUSE CATK_MOUSE]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). | [[http://www.uniprot.org/uniprot/CATK_MOUSE CATK_MOUSE]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). | ||
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| + | ==See Also== | ||
| + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Cathepsin K]] | [[Category: Cathepsin K]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Aguda, A]] | [[Category: Aguda, A]] | ||
[[Category: Brayer, G]] | [[Category: Brayer, G]] | ||
Revision as of 08:35, 8 January 2020
Crystal structure of T101A variant mouse cathepsin K at 2.94 Angstrom resolution.
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Categories: Cathepsin K | Large Structures | Lk3 transgenic mice | Aguda, A | Brayer, G | Bromme, D | Law, S | Cathepsin k | Hydrolase | Mouse
