Sandbox Reserved 1092

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Myostatin <ref name="edumont">Université de Montpellier. Physiologie et médecien fondamentale du coeur et des muscles : myostatine. [https://u1046.edu.umontpellier.fr/163-2/abrege-des-proteines-musculaires/myostatine/]</ref> is a protein that has a control over muscle development: it is a negative regulator of squeletics muscles. It has a very important role during the development of the animals but also during its whole life. It is a very important protein that is very conserved from zebra fish to humans <ref name="patho">PMID:19412331</ref> and so it has to be very well regulated. Indeed, there are many ways that regulates the action of this protein and at many scales.
Myostatin <ref name="edumont">Université de Montpellier. Physiologie et médecien fondamentale du coeur et des muscles : myostatine. [https://u1046.edu.umontpellier.fr/163-2/abrege-des-proteines-musculaires/myostatine/]</ref> is a protein that has a control over muscle development: it is a negative regulator of squeletics muscles. It has a very important role during the development of the animals but also during its whole life. It is a very important protein that is very conserved from zebra fish to humans <ref name="patho">PMID:19412331</ref> and so it has to be very well regulated. Indeed, there are many ways that regulates the action of this protein and at many scales.
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It is a grown factor<ref name="patho"/> that is implicated into muscle development in mammals. Myostatin can transmit a message to the nucleus that will promote a gene that lead to the production of ubiquitin. Ubiquitin is a signal of degradation so muscle cells will be destroyed. Indeed, it reduce the mass of the muscle but it also reduces the quantity of {{:Myosin}} <ref>Jeffrey L. Corden,David Tollervey. Cell Biology, Chapter 36 Motor Proteins.2017 [https://doi.org/10.1016/B978-0-323-34126-4.00036-0 DOI:10.1016/B978-0-323-34126-4.00036-0] </ref> which is very important for the cohesion of muscles and for movement. Indeed myosin forms filament, and when myosin filaments associate with actin and consume ATP it produce muscle movement.
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It is a grown factor<ref name="patho"/> that is implicated into muscle development in mammals. Myostatin can transmit a message to the nucleus that will promote a gene that lead to the production of ubiquitin. Ubiquitin is a signal of degradation so muscle cells will be destroyed. Indeed, it reduce the mass of the muscle but it also reduces the quantity of #REDIRECT[[Myosin]] <ref>Jeffrey L. Corden,David Tollervey. Cell Biology, Chapter 36 Motor Proteins.2017 [https://doi.org/10.1016/B978-0-323-34126-4.00036-0 DOI:10.1016/B978-0-323-34126-4.00036-0] </ref> which is very important for the cohesion of muscles and for movement. Indeed myosin forms filament, and when myosin filaments associate with actin and consume ATP it produce muscle movement.

Revision as of 16:16, 11 January 2020

This Sandbox is Reserved from 25/11/2019, through 30/9/2020 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1091 through Sandbox Reserved 1115.
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5JI1 : Myostatin (GDF8)

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Université de Montpellier. Physiologie et médecien fondamentale du coeur et des muscles : myostatine. [1]
  4. ↑ 4.0 4.1 Carnac G, Vernus B, Bonnieu A. Myostatin in the pathophysiology of skeletal muscle. Curr Genomics. 2007 Nov;8(7):415-22. doi: 10.2174/138920207783591672. PMID:19412331 doi:http://dx.doi.org/10.2174/138920207783591672
  5. ↑ Jeffrey L. Corden,David Tollervey. Cell Biology, Chapter 36 Motor Proteins.2017 DOI:10.1016/B978-0-323-34126-4.00036-0
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