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Insulin-like growth factor
From Proteopedia
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== Function == | == Function == | ||
'''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme<ref>PMID:15797461</ref>.<br /> | '''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme<ref>PMID:15797461</ref>.<br /> | ||
| - | * '''IGF I''' is secreted in the liver after stimulation by growth hormone. See details in [[IGF1]]<br /> | + | * '''IGF I''' is secreted in the liver after stimulation by growth hormone. See details in [[IGF1]] and [[Igf1 - alec]].<br /> |
* '''IGF II''' is required in early development stages. | * '''IGF II''' is required in early development stages. | ||
Revision as of 10:40, 12 January 2020
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3D structures of insulin-like growth factor
Updated on 12-January-2020
References
- ↑ Wood AW, Duan C, Bern HA. Insulin-like growth factor signaling in fish. Int Rev Cytol. 2005;243:215-85. PMID:15797461 doi:http://dx.doi.org/10.1016/S0074-7696(05)43004-1
- ↑ Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001 Nov;131(11 Suppl):3109S-20S. PMID:11694656
- ↑ Mohamed-Ali V, Pinkney J. Therapeutic potential of insulin-like growth factor-1 in patients with diabetes mellitus. Treat Endocrinol. 2002;1(6):399-410. PMID:15832492
