Sandbox Reserved 1095
From Proteopedia
(Difference between revisions)
Line 16: | Line 16: | ||
=== Ligand binding pocket === | === Ligand binding pocket === | ||
- | In the extracellular environement, there is a beta-hairpin in conjugaison with two extracellular disulfure bridges. This structure is responsible | + | In the extracellular environement, there is a beta-hairpin in conjugaison with two extracellular disulfure bridges. This structure is responsible for the oppening and the locking of the ligand binding pocket <ref> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605637/ </ref>. The ligand go into an <scene name='82/829348/Ligand_blinding_pocket/1'>hydrophilic pocket</scene> created into the membrane thanks to the 7 alpha helix which creat gate between th membrane and the extracellular environnement. |
=== G protein-binding site === | === G protein-binding site === |
Revision as of 14:12, 12 January 2020
This Sandbox is Reserved from 25/11/2019, through 30/9/2020 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1091 through Sandbox Reserved 1115. |
To get started:
More help: Help:Editing |
Human Angiotensin Receptor
Angiotensin receptors belongs to the G protein coupled receptor (GPCR). It is a membrane protein located mainly in heart, brain, liver and kidneys.
|
References
- ↑ https://www.researchgate.net/profile/Marc_De_Gasparo/publication/238340301_Les_rcepteurs_AT1_et_AT2_de_langiotensine_II_Lessentiel/links/567d3a9308aebccc4e03e6df.pdf
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705918/
- ↑ http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605637/
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457125/#!po=8.33333
- ↑ http://www.jbc.org/content/290/49/29127
- ↑ http://www.jbc.org/content/290/49/29127
- ↑ https://doi.org/10.1016/j.phrs.2017.06.013
- ↑ https://doi.org/10.1016/j.phrs.2017.06.013
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.