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1ab2

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[[Image:1ab2.gif|left|200px]]
[[Image:1ab2.gif|left|200px]]
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{{Structure
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|PDB= 1ab2 |SIZE=350|CAPTION= <scene name='initialview01'>1ab2</scene>
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The line below this paragraph, containing "STRUCTURE_1ab2", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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{{STRUCTURE_1ab2| PDB=1ab2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ab2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ab2 OCA], [http://www.ebi.ac.uk/pdbsum/1ab2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ab2 RCSB]</span>
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'''THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL'''
'''THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL'''
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[[Category: Overduin, M.]]
[[Category: Overduin, M.]]
[[Category: Rios, C B.]]
[[Category: Rios, C B.]]
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[[Category: transferase(phosphotransferase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:03:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:36:53 2008''
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Revision as of 07:03, 2 May 2008

Image:1ab2.gif

Template:STRUCTURE 1ab2

THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL


Overview

SH2 regions are protein motifs capable of binding target protein sequences that contain a phosphotyrosine. The solution structure of the abl SH2 product, a protein of 109 residues and 12.1 kd, has been determined by multidimensional nuclear magnetic resonance spectroscopy. It is a compact spherical domain with a pair of three-stranded antiparallel beta sheets and a C-terminal alpha helix enclosing the hydrophobic core. Three arginines project from a short N-terminal alpha helix and one beta sheet into the putative phosphotyrosine-binding site, which lies on a face distal from the termini. Comparison with other SH2 sequences supports a common global fold and mode of phosphotyrosine binding for this family.

About this Structure

1AB2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional solution structure of the src homology 2 domain of c-abl., Overduin M, Rios CB, Mayer BJ, Baltimore D, Cowburn D, Cell. 1992 Aug 21;70(4):697-704. PMID:1505033 Page seeded by OCA on Fri May 2 10:03:43 2008

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