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Sandbox Reserved 1108
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(Difference between revisions)
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==4iv6== | ==4iv6== | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | + | 4iv6 is an enzyme ''Mycobacterium tuberculosis'' which get his structure analyzed by Baugh et al. [https://www.ncbi.nlm.nih.gov/pubmed/25613812] with other enzymes homologue in order to fight ''Mycobacterium tuberculosis'' relative infections. | |
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== Function == | == Function == | ||
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[[Other information]]: | [[Other information]]: | ||
| - | The enzyme from beef liver can accept acyl-chain lengths from 3 to 8 carbon atoms. From different organism the range can vary so we ignore if | + | The enzyme from beef liver can accept acyl-chain lengths from 3 to 8 carbon atoms. From different organism the range can vary so we ignore if ''Mycobacterium tuberculosis'' gets the same lengths resolution. |
The highest activity reported for beef liver enzyme was for substrates with 4 and 5 carbon acyl-chain lengths. | The highest activity reported for beef liver enzyme was for substrates with 4 and 5 carbon acyl-chain lengths. | ||
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4iv6 which belong to ''Mycobacterium tuberculosis'' was studied with other protein homolog. | 4iv6 which belong to ''Mycobacterium tuberculosis'' was studied with other protein homolog. | ||
They were chosen to be studied as potential TB-Drugs target | They were chosen to be studied as potential TB-Drugs target | ||
| - | Studies have been made on homolog similarities aimed on their active site because with the knowledges of many homolog active site structure and how they work, we can design a inhibitor of those enzyme which can stop essential reaction and reduce or stop '' | + | Studies have been made on homolog similarities aimed on their active site because with the knowledges of many homolog active site structure and how they work, we can design a inhibitor of those enzyme which can stop essential reaction and reduce or stop ''Mycobacterium tuberculosis'' infection. |
This strategy is called an « Homolog-rescue strategy ». | This strategy is called an « Homolog-rescue strategy ». | ||
This strategy can be generalized for other drug target for other diseases. | This strategy can be generalized for other drug target for other diseases. | ||
Revision as of 19:16, 16 January 2020
| This Sandbox is Reserved from 25/11/2019, through 30/9/2020 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1091 through Sandbox Reserved 1115. |
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4iv6
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