Serine/threonine protein kinase 3D structures

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==3D structures of serine/threonine protein kinase==
==3D structures of serine/threonine protein kinase==
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**[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
**[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
**[[6cpg]] – hChk6 kinase domain + inhibitor + monobody<br />
**[[6cpg]] – hChk6 kinase domain + inhibitor + monobody<br />
-
**[[3daj]], [[3d14]], [[3dj5]], [[3dj6]], [[3dj7]], [[3d15]], [[3d2i]], [[3d2k]] – Chk6 kinase domain (mutant) + inhibitor - mouse<br />
 
**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]] – hChk6 kinase domain + inhibitor<br />
**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]] – hChk6 kinase domain + inhibitor<br />
**[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]] – hChk6 kinase domain (mutant) + inhibitor<br />
**[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]] – hChk6 kinase domain (mutant) + inhibitor<br />
**[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
**[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
**[[5dos]], [[5dr2]] – hChk6 kinase domain (mutant) + ATP + inhibitor<br />
**[[5dos]], [[5dr2]] – hChk6 kinase domain (mutant) + ATP + inhibitor<br />
 +
**[[3daj]], [[3d14]], [[3dj5]], [[3dj6]], [[3dj7]], [[3d15]], [[3d2i]], [[3d2k]] – Chk6 kinase domain (mutant) + inhibitor - mouse<br />
*Chk6 with phosphorylated Thr 287, Thr288
*Chk6 with phosphorylated Thr 287, Thr288
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*Plk1 Polo-box domain (Pbd)''
*Plk1 Polo-box domain (Pbd)''
-
**[[1q4o]], [[2ogq]], [[3hih]], [[3p2w]], [[4h5x]] – Plk1 Pbd<br />
+
**[[1q4o]], [[2ogq]], [[3hih]], [[3p2w]], [[4h5x]] – hPlk1 Pbd<br />
*Plk1 Pbd complex with polypeptide
*Plk1 Pbd complex with polypeptide
-
**[[1umw]], [[2ojx]], [[3bzi]], [[3c5l]], [[3rq7]], [[4dfw]], [[4whl]], [[4whk]], [[4whh]], [[4rcp]], [[4o6w]], [[4o56]], [[5dms]], [[5dmv]], [[5dnj]] – Plk1 + peptide<br />
+
**[[1umw]], [[2ojx]], [[3bzi]], [[3c5l]], [[3rq7]], [[4dfw]], [[4whl]], [[4whk]], [[4whh]], [[4rcp]], [[4o6w]], [[4o56]], [[5dms]], [[5dmv]], [[5dnj]] – hPlk1 + peptide<br />
-
**[[3hik]], [[3fvh]], [[3p2z]], [[3p34]], [[3p35]], [[3p36]], [[3p37]], [[3q1i]], [[4e67]], [[4e9c]], [[4e9d]], [[4hab]], [[4hy2]], [[4o9w]], [[4x9r]], [[4x9v]], [[4x9w]], [[5j19]] – Plk1 + phosphopeptide<br />
+
**[[3hik]], [[3fvh]], [[3p2z]], [[3p34]], [[3p35]], [[3p36]], [[3p37]], [[3q1i]], [[4e67]], [[4e9c]], [[4e9d]], [[4hab]], [[4hy2]], [[4o9w]], [[4x9r]], [[4x9v]], [[4x9w]], [[5j19]] – hPlk1 + phosphopeptide<br />
-
**[[1q4k]] – Plk1 (mutant) + phosphopeptide<br />
+
**[[1q4k]] – hPlk1 (mutant) + phosphopeptide<br />
-
**[[2v5q]] – Plk1 + design ankyrin repeat protein<br />
+
**[[2v5q]] – hPlk1 + design ankyrin repeat protein<br />
**[[4lkl]] – hChk Plk1 + PL-55 <br />
**[[4lkl]] – hChk Plk1 + PL-55 <br />
**[[4lkm]] – hChk Plk1 + PL-74 <br />
**[[4lkm]] – hChk Plk1 + PL-74 <br />
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*Plk1 Pbd complex with small molecule inhibitor
*Plk1 Pbd complex with small molecule inhibitor
-
**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]] – Plk1 + inhibitor<br />
+
**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]] – hPlk1 + inhibitor<br />
-
**[[2rku]] – Plk1 (mutant) + inhibitor<br />
+
**[[2rku]] – hPlk1 (mutant) + inhibitor<br />
**[[3db6]], [[3db8]], [[3dbc]], [[3dbd]], [[3dbe]], [[3dbf]] – zfPlk1 (mutant) + inhibitor – zebra fish<br />
**[[3db6]], [[3db8]], [[3dbc]], [[3dbd]], [[3dbe]], [[3dbf]] – zfPlk1 (mutant) + inhibitor – zebra fish<br />
*Plk1 catalytic domain
*Plk1 catalytic domain
-
**[[2owb]] – Plk1 catalytic domain <br />
+
**[[2owb]] – hPlk1 catalytic domain (mutant)<br />
-
**[[2ou7]] – Plk1 catalytic domain + AMPPNP<br />
+
**[[2ou7]] – hPlk1 catalytic domain (mutant) + AM
-
**[[3d5w]] – zfPlk1 catalytic domain + ADP<br />
+
**[[3kb7]], [[2yac]], [[3thb]], [[4a4l]], [[4a4o]] – hPlk1 catalytic domain + inhibitor<br />
-
**[[3kb7]], [[2yac]], [[3thb]], [[4a4l]], [[4a4o]] – Plk1 catalytic domain + inhibitor<br />
+
**[[3fc2]] – hPlk1 catalytic domain (mutant) + inhibitor<br />
-
**[[3fc2]] – Plk1catalytic domain (mutant) + inhibitor<br />
+
**[[4j52]], [[4j53]] – hChk Plk1 (mutant) + inhibitor <br />
**[[4j52]], [[4j53]] – hChk Plk1 (mutant) + inhibitor <br />
**[[3d5x]] – zfPlk1 catalytic domain (mutant) + wortmannin<br />
**[[3d5x]] – zfPlk1 catalytic domain (mutant) + wortmannin<br />
 +
**[[3d5w]] – zfPlk1 catalytic domain + ADP<br />
*'''Plk2'''
*'''Plk2'''
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*'''Chk16'''
*'''Chk16'''
-
**[[2buj]] – hChk13 (mutant) + staurosporin <br />
+
**[[2buj]] – hChk16 (mutant) + staurosporin <br />
*'''Chk17'''
*'''Chk17'''
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**[[1rfa]] – hc-Raf RAS-binding domain - NMR<br />
**[[1rfa]] – hc-Raf RAS-binding domain - NMR<br />
-
**[[1rrb]] – c-Raf RAS-binding domain – NMR - rat<br />
 
**[[1faq]], [[1far]] – hc-Raf cysteine-rich domain - NMR<br />
**[[1faq]], [[1far]] – hc-Raf cysteine-rich domain - NMR<br />
**[[3omv]] – hc-Raf kinase domain <br />
**[[3omv]] – hc-Raf kinase domain <br />
 +
**[[1rrb]] – c-Raf RAS-binding domain – NMR - rat<br />
*c-Raf complex with protein
*c-Raf complex with protein
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*Chk Wnk (protein kinase lysine-deficient)
*Chk Wnk (protein kinase lysine-deficient)
-
**[[2lru]] – rChk Wnk1 autoinhibitory domain - NMR<br />
 
-
**[[5w7t]] - rChk Wnk1 kinase domain <br />
 
**[[6cn9]], [[4q2a]], [[4pwn]] - hChk Wnk1 kinase domain (mutant)<br />
**[[6cn9]], [[4q2a]], [[4pwn]] - hChk Wnk1 kinase domain (mutant)<br />
**[[5tf9]] - hChk Wnk1 kinase domain + inhibitor + AMPPNP<br />
**[[5tf9]] - hChk Wnk1 kinase domain + inhibitor + AMPPNP<br />
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**[[5o26]], [[5tf9]] - hChk Wnk3 kinase domain + AMPPNP<br />
**[[5o26]], [[5tf9]] - hChk Wnk3 kinase domain + AMPPNP<br />
**[[5o2b]] - hChk Wnk3 kinase domain + inhibitor<br />
**[[5o2b]] - hChk Wnk3 kinase domain + inhibitor<br />
 +
**[[2lru]] – rChk Wnk1 autoinhibitory domain - NMR<br />
 +
**[[5w7t]] - rChk Wnk1 kinase domain <br />
*'''TANK-binding kinase'''
*'''TANK-binding kinase'''
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**[[6c9d]] – hChk MARK1 catalytic+UBA+KA1 domains (mutant)<br />
**[[6c9d]] – hChk MARK1 catalytic+UBA+KA1 domains (mutant)<br />
**[[5eak]], [[5kz7]], [[5kz8]] – hChk MARK2 catalytic+UBA domains + inhibitor <br />
**[[5eak]], [[5kz7]], [[5kz8]] – hChk MARK2 catalytic+UBA domains + inhibitor <br />
-
**[[1zmu]] – rChk MARK2 catalytic+UBA domains <br />
 
-
**[[2wzj]], [[2r0i]], [[1zmv]], [[1y8g]], [[1zmw]] – rChk MARK2 catalytic+UBA domains (mutant)<br />
 
**[[3iec]] – hChk MARK2 catalytic+UBA domains + cytotoxicity-associated immunodominant antigen peptide<br />
**[[3iec]] – hChk MARK2 catalytic+UBA domains + cytotoxicity-associated immunodominant antigen peptide<br />
**[[2qnj]] – hChk MARK3 catalytic+UBA domains <br />
**[[2qnj]] – hChk MARK3 catalytic+UBA domains <br />
-
**[[1ul7]], [[1v5s]] - mChk MARK3 catalytic domain – mouse - NMR<br />
 
**[[3fe3]] – hChk MARK3 catalytic+UBA domains (mutant)<br />
**[[3fe3]] – hChk MARK3 catalytic+UBA domains (mutant)<br />
**[[5es1]] – hChk MARK4 catalytic+UBA domains + inhibitor<br />
**[[5es1]] – hChk MARK4 catalytic+UBA domains + inhibitor<br />
 +
**[[1zmu]] – rChk MARK2 catalytic+UBA domains <br />
 +
**[[2wzj]], [[2r0i]], [[1zmv]], [[1y8g]], [[1zmw]] – rChk MARK2 catalytic+UBA domains (mutant)<br />
 +
**[[1ul7]], [[1v5s]] - mChk MARK3 catalytic domain - NMR<br />
*'''Mitotic checkpoint Chk (Bub)'''; Domains: TPR 1-220; kinase 726-1085
*'''Mitotic checkpoint Chk (Bub)'''; Domains: TPR 1-220; kinase 726-1085
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*'''Other Chk'''
*'''Other Chk'''
-
**[[1u5q]], [[1u5r]] – rChk Tao2 kinase domain <br />
 
-
**[[2cos]] – Chk Lats2 – mouse – NMR<br />
 
**[[1wak]] – hChk Sprk1 <br />
**[[1wak]] – hChk Sprk1 <br />
**[[3dak]] – hChk Osr1 kinase domain <br />
**[[3dak]] – hChk Osr1 kinase domain <br />
**[[4aw2]] – hChk Mrckα kinase domain<br />
**[[4aw2]] – hChk Mrckα kinase domain<br />
**[[4pxw]] – hChk Vprbp WD repeat domain (mutant)<br />
**[[4pxw]] – hChk Vprbp WD repeat domain (mutant)<br />
-
**[[1q8z]], [[1zyc]] – yChk <br />
 
-
**[[1how]], [[1zxe]], [[1zy4]] – yChk (mutant)<br />
 
-
**[[1ow5]], [[1x9x]] – yChk Ste11 SAM domain – NMR<br />
 
-
**[[2kio]], [[2kit]], [[1w1n]] – yChk Tor1 FATC domain – NMR<br />
 
-
**[[3gre]] – yChk Vps15 WD repeat domain<br />
 
-
**[[3osm]], [[3ost]] - yChk Kcc4 kinase domain <br />
 
**[[1uf0]] – hChk Dcamkl1 DCX domain – NMR<br />
**[[1uf0]] – hChk Dcamkl1 DCX domain – NMR<br />
 +
**[[1u5q]], [[1u5r]] – rChk Tao2 kinase domain <br />
 +
**[[2cos]] – mChk Lats2 – NMR<br />
**[[1xte]], [[1xtn]], [[6edx]] – mChk Sgk3 PX domain <br />
**[[1xte]], [[1xtn]], [[6edx]] – mChk Sgk3 PX domain <br />
-
**[[4f0g]] – smChk Roco4 kinase domain – slime mold<br />
 
**[[4yom]] – mChk Sad <br />
**[[4yom]] – mChk Sad <br />
**[[4ynz]] – mChk Sad N terminal domain <br />
**[[4ynz]] – mChk Sad N terminal domain <br />
**[[5iri]] – mChk Sad residues 592-719<br />
**[[5iri]] – mChk Sad residues 592-719<br />
**[[5oat]] – Chk – red flour beetle <br />
**[[5oat]] – Chk – red flour beetle <br />
 +
**[[4f0g]] – smChk Roco4 kinase domain – slime mold<br />
 +
**[[1q8z]], [[1zyc]] – yChk <br />
 +
**[[1how]], [[1zxe]], [[1zy4]] – yChk (mutant)<br />
 +
**[[1ow5]], [[1x9x]] – yChk Ste11 SAM domain – NMR<br />
 +
**[[2kio]], [[2kit]], [[1w1n]] – yChk Tor1 FATC domain – NMR<br />
 +
**[[3gre]] – yChk Vps15 WD repeat domain<br />
 +
**[[3osm]], [[3ost]] - yChk Kcc4 kinase domain <br />
*Other Chk complexes
*Other Chk complexes
-
**[[2gcd]] – rChk Tao2 kinase domain + staurosporine<br />
 
-
**[[3hgk]] – Chk Pto + effector protein AVRPTOB – Currant tomato<br />
 
**[[1wbp]] – hChk Sprk1 + peptide<br />
**[[1wbp]] – hChk Sprk1 + peptide<br />
**[[3beg]] – hChk Srpk1 + splicing factor SF2<br />
**[[3beg]] – hChk Srpk1 + splicing factor SF2<br />
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**[[5jk7]] – hChk Vprbp WD repeat domain + VPX + DDB1 + UDG<br />
**[[5jk7]] – hChk Vprbp WD repeat domain + VPX + DDB1 + UDG<br />
**[[3wa0]], [[4p7i]] – hChk Vprbp residues 1417-1506 + merlin<br />
**[[3wa0]], [[4p7i]] – hChk Vprbp residues 1417-1506 + merlin<br />
-
**[[5fvm]] - Tor2 + LST8 - ''Kluyveromyces marxianus''<br />
 
-
**[[5kc2]] - yVps15 + Vps34 - Cryo EM<br />
 
-
**[[5dfz]] - yVps15 + Vps34 + Vps30 + VPSAP28 + VPSAP30 - Cryo EM<br />
 
**[[4wzx]] – hChk Ulk3 MIT 2 domain + inhibitor<br />
**[[4wzx]] – hChk Ulk3 MIT 2 domain + inhibitor<br />
**[[5ci7]] – hChk Ulk1 (mutant) + inhibitor<br />
**[[5ci7]] – hChk Ulk1 (mutant) + inhibitor<br />
**[[4wnp]], [[4wno]] – hChk Ulk1 + IST1 homolog<br />
**[[4wnp]], [[4wno]] – hChk Ulk1 + IST1 homolog<br />
**[[5b5w]], [[5b6b]], [[5brk]] – hChk Lats1 residues 622-704 + MOB1 <br />
**[[5b5w]], [[5b6b]], [[5brk]] – hChk Lats1 residues 622-704 + MOB1 <br />
 +
**[[2gcd]] – rChk Tao2 kinase domain + staurosporine<br />
 +
**[[3hgk]] – Chk Pto + effector protein AVRPTOB – Currant tomato<br />
 +
**[[4f0f]] – smChk Roco4 kinase domain + APPCP <br />
 +
**[[4f1m]], [[4f1o]] – smChk Roco4 kinase domain (mutant) + APPCP <br />
 +
**[[4f1t]] – smChk Roco4 kinase domain + inhibitor <br />
 +
**[[5fvm]] - Tor2 + LST8 - ''Kluyveromyces marxianus''<br />
 +
**[[5kc2]] - yVps15 + Vps34 - Cryo EM<br />
 +
**[[5dfz]] - yVps15 + Vps34 + Vps30 + VPSAP28 + VPSAP30 - Cryo EM<br />
**[[1q8y]], [[1q97]], [[1q99]], [[1zyd]] – yChk + nucleotide<br />
**[[1q8y]], [[1q97]], [[1q99]], [[1zyd]] – yChk + nucleotide<br />
**[[1zy5]] – yChk (mutant) + nucleotide<br />
**[[1zy5]] – yChk (mutant) + nucleotide<br />
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**[[4lqs]], [[4lqq]], [[4lqp]] – yChk Cbk1 residues 251-756 + Cbk1 activator Mob2<br />
**[[4lqs]], [[4lqq]], [[4lqp]] – yChk Cbk1 residues 251-756 + Cbk1 activator Mob2<br />
**[[3p86]], [[3ppz]] - AtChk Ctr1 + staurosporine<br />
**[[3p86]], [[3ppz]] - AtChk Ctr1 + staurosporine<br />
-
**[[4f0f]] – smChk Roco4 kinase domain + APPCP <br />
 
-
**[[4f1m]], [[4f1o]] – smChk Roco4 kinase domain (mutant) + APPCP <br />
 
-
**[[4f1t]] – smChk Roco4 kinase domain + inhibitor <br />
 
*Serine/threonine protein kinase Rad53 see [[Rad53]]
*Serine/threonine protein kinase Rad53 see [[Rad53]]

Revision as of 11:22, 22 January 2020

3D structures of serine/threonine protein kinase

Updated on 22-January-2020

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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