1ad2

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[[Image:1ad2.gif|left|200px]]
[[Image:1ad2.gif|left|200px]]
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{{Structure
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|PDB= 1ad2 |SIZE=350|CAPTION= <scene name='initialview01'>1ad2</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1ad2", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_1ad2| PDB=1ad2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ad2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ad2 OCA], [http://www.ebi.ac.uk/pdbsum/1ad2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ad2 RCSB]</span>
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'''RIBOSOMAL PROTEIN L1 MUTANT WITH SERINE 179 REPLACED BY CYSTEINE'''
'''RIBOSOMAL PROTEIN L1 MUTANT WITH SERINE 179 REPLACED BY CYSTEINE'''
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[[Category: Ossina, N.]]
[[Category: Ossina, N.]]
[[Category: Unge, J.]]
[[Category: Unge, J.]]
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[[Category: mutant]]
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[[Category: Mutant]]
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[[Category: protein synthesis]]
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[[Category: Protein synthesis]]
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[[Category: ribosomal protein]]
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[[Category: Ribosomal protein]]
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[[Category: rna binding]]
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[[Category: Rna binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:06:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:37:46 2008''
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Revision as of 07:06, 2 May 2008

Image:1ad2.gif

Template:STRUCTURE 1ad2

RIBOSOMAL PROTEIN L1 MUTANT WITH SERINE 179 REPLACED BY CYSTEINE


Overview

The crystal structure of the mutant S179C of the ribosomal protein L1 from Thermus thermophilus has been determined at 1.9 A resolution. The mutant molecule displays a small but significant opening of the cavity between the two domains. The domain movement seems to be facilitated by the flexibility of at least two conserved glycines. These glycines may be necessary for the larger conformational change needed for an induced fit mechanism upon binding RNA. The domain movement makes a disulfide bridge possible between the incorporated cysteines in two monomers of the mutant L1.

About this Structure

1AD2 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

A mutant form of the ribosomal protein L1 reveals conformational flexibility., Unge J, Al-Karadaghi S, Liljas A, Jonsson BH, Eliseikina I, Ossina N, Nevskaya N, Fomenkova N, Garber M, Nikonov S, FEBS Lett. 1997 Jul 7;411(1):53-9. PMID:9247141 Page seeded by OCA on Fri May 2 10:06:56 2008

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