6h05
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-electron microscopic structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate (2-oxoglutarate) dehydrogenase complex [residues 218-453]== | |
| - | + | <StructureSection load='6h05' size='340' side='right'caption='[[6h05]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6h05]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H05 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h05 OCA], [http://pdbe.org/6h05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h05 RCSB], [http://www.ebi.ac.uk/pdbsum/6h05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h05 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ODO2_HUMAN ODO2_HUMAN]] Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).[UniProtKB:Q9N0F1]<ref>PMID:29211711</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dihydrolipoyllysine-residue succinyltransferase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Adam-Vizi, V]] | ||
| + | [[Category: Ambrus, A]] | ||
| + | [[Category: Hubert, A]] | ||
| + | [[Category: Jordan, F]] | ||
| + | [[Category: Nagy, B]] | ||
| + | [[Category: Nemeria, N S]] | ||
| + | [[Category: Novacek, J]] | ||
| + | [[Category: Polak, M]] | ||
| + | [[Category: Zambo, Z]] | ||
| + | [[Category: 2-oxoglutarate dehydrogenase complex]] | ||
| + | [[Category: Alpha-ketoglutarate dehydrogenase complex]] | ||
| + | [[Category: Dihydrolipoamide succinyltransferase]] | ||
| + | [[Category: E2 component]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 16:05, 22 January 2020
Cryo-electron microscopic structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate (2-oxoglutarate) dehydrogenase complex [residues 218-453]
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Categories: Dihydrolipoyllysine-residue succinyltransferase | Large Structures | Adam-Vizi, V | Ambrus, A | Hubert, A | Jordan, F | Nagy, B | Nemeria, N S | Novacek, J | Polak, M | Zambo, Z | 2-oxoglutarate dehydrogenase complex | Alpha-ketoglutarate dehydrogenase complex | Dihydrolipoamide succinyltransferase | E2 component | Transferase
