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6jfv
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of tetrameric 2B-2B complex from keratins 5 and 14 (C367A mutant of K14)== |
| - | + | <StructureSection load='6jfv' size='340' side='right'caption='[[6jfv]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6jfv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JFV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jfv OCA], [http://pdbe.org/6jfv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jfv RCSB], [http://www.ebi.ac.uk/pdbsum/6jfv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jfv ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/K1C14_HUMAN K1C14_HUMAN]] Epidermolysis bullosa simplex, Dowling-Meara type;Localized epidermolysis bullosa simplex;Dermatopathia pigmentosa reticularis;Naegeli-Franceschetti-Jadassohn syndrome;Epidermolysis bullosa simplex with mottled pigmentation;Generalized epidermolysis bullosa simplex, non-Dowling-Meara type;KRT14-related epidermolysis bullosa simplex. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/K2C5_HUMAN K2C5_HUMAN]] Epidermolysis bullosa simplex, Dowling-Meara type;Localized epidermolysis bullosa simplex;Epidermolysis bullosa simplex with circinate migratory erythema;Epidermolysis bullosa simplex with mottled pigmentation;Dowling-Degos disease;Generalized epidermolysis bullosa simplex, non-Dowling-Meara type. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/K1C14_HUMAN K1C14_HUMAN]] The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.<ref>PMID:11724817</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Coulombe, P A]] | ||
| + | [[Category: Kim, M S]] | ||
| + | [[Category: Leahy, D J]] | ||
| + | [[Category: Lee, C H]] | ||
| + | [[Category: Cytosolic protein]] | ||
| + | [[Category: Epithelium]] | ||
| + | [[Category: Intermediate filament]] | ||
| + | [[Category: Keratinocyte]] | ||
| + | [[Category: Protein self-assembly]] | ||
| + | [[Category: Skin]] | ||
Revision as of 16:08, 22 January 2020
The crystal structure of tetrameric 2B-2B complex from keratins 5 and 14 (C367A mutant of K14)
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