6now
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Alanyl-tRNA Synthetase C-Ala domain== | |
| - | + | <StructureSection load='6now' size='340' side='right'caption='[[6now]], [[Resolution|resolution]] 4.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6now]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NOW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine--tRNA_ligase Alanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [http://pdbe.org/6now PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [http://www.ebi.ac.uk/pdbsum/6now PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Combined oxidative phosphorylation defect type 8;Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia;Ovarioleukodystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Alanine--tRNA ligase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kuhle, B]] | ||
[[Category: Schimmel, P]] | [[Category: Schimmel, P]] | ||
| - | [[Category: | + | [[Category: Alanyl-trna synthetase]] |
| + | [[Category: Alpha-beta domain]] | ||
| + | [[Category: C-terminal domain]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Mitochondria]] | ||
Revision as of 16:11, 22 January 2020
Human Alanyl-tRNA Synthetase C-Ala domain
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